Research workbench
AlphaFold monomer V2.0 prediction for double-strand break repair protein MRE11 (P49959)
Analyse AlphaFold monomer V2.0 prediction for double-strand break repair protein MRE11… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P49959
- Type
- protein
- Length
- 708 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xFe0F6F52e06108B713093Cf01406F947Bc410fED
- Molecule
- Double-strand break repair protein MRE11
- UniProt
- P49959
- Pockets
- 5 · best druggability 0.49
Structure
1 distinct chain · 28% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Double-strand break repair protein MRE11 | protein | 708 | 28% helix, 14% strand | P49959 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.49 | 0.73 | 39 | empty |
| 2 | 60 | 0.48 | 0.85 | 14 | empty |
| 3 | 88 | 0.47 | 0.81 | 19 | empty |
| 4 | 161 | 0.41 | 0.73 | 27 | empty |
| 5 | 133 | 0.37 | 0.73 | 23 | empty |
Compared structures
- 8BAH · Human Mre11-Nbs1 complex · an experimental structure of the same protein · chain A against A, TM-score 0.56
- 3T1I · Crystal structure of human MRE11: understanding tumorigenic mutations · an experimental structure of the same protein · chain A against D, TM-score 0.54
- 3T1I · Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations · an experimental structure of the same protein · chain A against D, TM-score 0.54
- 8K00 · RPA70N-MRE11 fusion · an experimental structure of the same protein · chain A against B, TM-score 0.04
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49959
- Elsewhere: UniProt P49959 · AlphaFold DB P49959
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