UniProt P49959

Double-strand break repair protein MRE11 (P49959)

Double-strand break repair protein MRE11 (UniProt P49959), EC 3.1.-.-: 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 16 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P49959
Protein: Double-strand break repair protein MRE11
EC: 3.1.-.-
Experimental structures: 3
Predicted models: 1
Ligands: 1
Pockets: 16 · 1 record with a druggable one

Structures

4 records of P49959 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3T1I	Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations	x-ray diffraction	A, B, C, D	—	—
3T1I	Crystal structure of human MRE11: understanding tumorigenic mutations	x-ray diffraction	A, B, C, D	—	—
8BAH	Human Mre11-Nbs1 complex	electron microscopy	A, B	MN	11 (best 0.58)
P49959	AlphaFold monomer V2.0 prediction for double-strand break repair protein MRE11 (P49959)	predicted	A	—	5 (best 0.49)

Ligands

MN · Manganese (II) ion · in 1 record

Experiment against prediction

3T1I chain A against the predicted model P49959: TM-score 0.99, RMSD 0.57 Å
3T1I chain A against the predicted model P49959: TM-score 0.99, RMSD 0.57 Å
3T1I chain B against the predicted model P49959: TM-score 0.99, RMSD 0.59 Å
3T1I chain B against the predicted model P49959: TM-score 0.99, RMSD 0.59 Å
3T1I chain C against the predicted model P49959: TM-score 0.99, RMSD 0.71 Å
3T1I chain C against the predicted model P49959: TM-score 0.99, RMSD 0.71 Å
3T1I chain D against the predicted model P49959: TM-score 0.98, RMSD 1.29 Å
3T1I chain D against the predicted model P49959: TM-score 0.98, RMSD 1.29 Å
8BAH chain B against the predicted model P49959: TM-score 0.98, RMSD 1.39 Å
8BAH chain A against the predicted model P49959: TM-score 0.98, RMSD 1.43 Å

Elsewhere

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