Research workbench
AlphaFold monomer V2.0 prediction for N-lysine methyltransferase KMT5A (Q9NQR1)
Analyse AlphaFold monomer V2.0 prediction for N-lysine methyltransferase KMT5A (Q9NQR1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q9NQR1
- Type
- protein
- Length
- 393 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf4ED13986579E8e227b3ED6c02276c648754EC27
- Molecule
- N-lysine methyltransferase KMT5A
- UniProt
- Q9NQR1
- Pockets
- 2 · best druggability 0.64
Structure
1 distinct chain · 11% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-lysine methyltransferase KMT5A | protein | 393 | 11% helix, 14% strand | Q9NQR1 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 295 | 0.64 | 0.80 | 37 | empty |
| 2 | 169 | 0.41 | 0.73 | 32 | empty |
Compared structures
- 7XPX · Cryo-EM structure of the histone methyltransferase SET8 bound to H4K20Ecx-nucleosome · an experimental structure of the same protein · chain A against K, TM-score 0.42
- 7XPX · Cryo-EM structure of the histone methyltransferase SET8 bound to H4K20ECX-nucleosome · an experimental structure of the same protein · chain A against K, TM-score 0.42
- 1ZKK · Crystal structure of HSET8 in ternary complex with H4 peptide (16-24) and adohcy · an experimental structure of the same protein · chain A against B, TM-score 0.41
- 1ZKK · Crystal structure of hSET8 in ternary complex with H4 peptide (16-24) and AdoHcy · an experimental structure of the same protein · chain A against B, TM-score 0.41
- 3F9Z · Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases… · an experimental structure of the same protein · chain A against B, TM-score 0.41
- 3F9Z · Structural insights into lysine multiple methylation by set domain methyltransferases… · an experimental structure of the same protein · chain A against B, TM-score 0.41
- 7D20 · Cryo-EM structure of SET8-cenp-a-nucleosome complex · an experimental structure of the same protein · chain A against K, TM-score 0.41
- 7D20 · Cryo-EM structure of SET8-CENP-A-nucleosome complex · an experimental structure of the same protein · chain A against K, TM-score 0.41
- 7D1Z · Cryo-EM structure of SET8-nucleosome complex · an experimental structure of the same protein · chain A against K, TM-score 0.41
- 7D1Z · Cryo-EM structure of SET8-nucleosome complex · an experimental structure of the same protein · chain A against K, TM-score 0.41
- 3F9X · Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases… · an experimental structure of the same protein · chain A against D, TM-score 0.41
- 3F9X · Structural insights into lysine multiple methylation by set domain methyltransferases… · an experimental structure of the same protein · chain A against D, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NQR1
- Elsewhere: UniProt Q9NQR1 · AlphaFold DB Q9NQR1
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