Research workbench
AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q08881)
Analyse AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q08881) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- Q08881
- Type
- protein
- Length
- 620 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x35612D34a32C306CA4fc1edA9360D1F717e25950
- Molecule
- Tyrosine-protein kinase ITK/TSK
- UniProt
- Q08881
- Pockets
- 7 · best druggability 0.80
Structure
1 distinct chain · 26% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase ITK/TSK | protein | 620 | 26% helix, 27% strand | Q08881 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 996 | 0.80 | 0.82 | 82 | empty |
| 2 | 233 | 0.60 | 0.80 | 25 | empty |
| 3 | 121 | 0.55 | 0.82 | 20 | empty |
| 4 | 70 | 0.47 | 0.83 | 16 | empty |
| 5 | 107 | 0.44 | 0.78 | 15 | empty |
Compared structures
- 4HCT · Crystal structure of itk in complex with compound 52 · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 4HCT · Crystal structure of ITK in complex with compound 52 · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 4HCU · Crystal structure of ITK in complext with compound 40 · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 4HCU · Crystal structure of itk in complext with compound 40 · an experimental structure of the same protein · chain A against A, TM-score 0.42
- 4M13 · Crystal structure of ITK in complex with compound 8… · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4M13 · Crystal structure of itk in complex with compound 8 [4… · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4HCV · Crystal structure of itk in complex with compound 53 · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4HCV · Crystal structure of ITK in complex with compound 53 · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4M0Z · Crystal structure of ITK in complex with compound 5… · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4M0Z · Crystal structure of itk in complex with compound 5 {4… · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4M12 · Crystal structure of ITK in complex with compound 7… · an experimental structure of the same protein · chain A against A, TM-score 0.41
- 4M12 · Crystal structure of itk in complex with compound 7 [4… · an experimental structure of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08881
- Elsewhere: UniProt Q08881 · AlphaFold DB Q08881
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.