UniProt Q08881
Q08881
Q08881 (UniProt Q08881): 72 experimental structures and 1 predicted model on GenesisL1. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q08881
- Experimental structures
- 72
- Predicted models
- 1
Structures
73 records of Q08881 in the MolNFT archive: 72 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1SM2 | Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 1SM2 | Crystal structure of the phosphorylated interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 1SNU | Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 1SNU | Crystal structure of the unphosphorylated interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 1SNX | Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 1SNX | Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain | x-ray diffraction | A, B | — | — |
| 2E6I | Solution structure of the BTK motif of tyrosine-protein kinase ITK from human | solution nmr | A | — | — |
| 2E6I | Solution structure of the btk motif of tyrosine-protein kinase itk from human | solution nmr | A | — | — |
| 2LMJ | Itk-sh3 | solution nmr | A | — | — |
| 2LMJ | ITK-SH3 | solution nmr | A | — | — |
| 2YUQ | Solution structure of the SH3 domain of human Tyrosine-protein kinase ITK/TSK | solution nmr | A | — | — |
| 2YUQ | Solution structure of the SH3 domain of human tyrosine-protein kinase ITK/TSK | solution nmr | A | — | — |
| 3MIY | X-ray crystal structure of ITK complexed with sunitinib | x-ray diffraction | A, B | — | — |
| 3MIY | X-ray crystal structure of itk complexed with sunitinib | x-ray diffraction | A, B | — | — |
| 3MJ1 | X-ray crystal structure of ITK complexed with inhibitor RO5191614 | x-ray diffraction | A | — | — |
| 3MJ1 | X-ray crystal structure of itk complexed with inhibitor RO5191614 | x-ray diffraction | A | — | — |
| 3MJ2 | X-ray crystal structure of ITK complexed with inhibitor BMS-509744 | x-ray diffraction | A | — | — |
| 3MJ2 | X-ray crystal structure of itk complexed with inhibitor bms-509744 | x-ray diffraction | A | — | — |
| 3QGW | Crystal Structure of ITK kinase bound to an inhibitor | x-ray diffraction | A, B | — | — |
| 3QGW | Crystal structure of itk kinase bound to an inhibitor | x-ray diffraction | A, B | — | — |
| 3QGY | Crystal structure of ITK inhibitor complex | x-ray diffraction | A, B | — | — |
| 3QGY | Crystal structure of itk inhibitor complex | x-ray diffraction | A, B | — | — |
| 3T9T | Crystal structure of BTK mutant (F435T,K596R) complexed with Imidazo[1,5-a]quinoxaline | x-ray diffraction | A | — | — |
| 3T9T | Crystal structure of btk mutant (F435T,K596R) complexed with IMIDAZO[1,5-A]QUINOXALINE | x-ray diffraction | A | — | — |
| 3V5J | Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with… | x-ray diffraction | A, B | — | — |
| 3V5J | Crystal structure of interleukin-2 inducible T-cell kinase itk catalytic domain with… | x-ray diffraction | A, B | — | — |
| 3V5L | Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with… | x-ray diffraction | A, B, C, D | — | — |
| 3V5L | Crystal structure of interleukin-2 inducible T-cell kinase itk catalytic domain with… | x-ray diffraction | A, B, C, D | — | — |
| 3V8T | Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with… | x-ray diffraction | A, B | — | — |
| 3V8T | Crystal structure of interleukin-2 inducible T-cell kinase itk catalytic domain with… | x-ray diffraction | A, B | — | — |
| 3V8W | Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with… | x-ray diffraction | A, B | — | — |
| 3V8W | Crystal structure of interleukin-2 inducible T-cell kinase itk catalytic domain with… | x-ray diffraction | A, B | — | — |
| 4HCT | Crystal structure of ITK in complex with compound 52 | x-ray diffraction | A | — | — |
| 4HCT | Crystal structure of itk in complex with compound 52 | x-ray diffraction | A | — | — |
| 4HCU | Crystal structure of ITK in complext with compound 40 | x-ray diffraction | A | — | — |
| 4HCU | Crystal structure of itk in complext with compound 40 | x-ray diffraction | A | — | — |
| 4HCV | Crystal structure of ITK in complex with compound 53 | x-ray diffraction | A | — | — |
| 4HCV | Crystal structure of itk in complex with compound 53 | x-ray diffraction | A | — | — |
| 4KIO | Kinase domain mutant of human Itk in complex with a covalently-binding inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4KIO | Kinase domain mutant of human itk in complex with a covalently-binding inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4L7S | Kinase domain mutant of human Itk in complex with an aminobenzothiazole inhibitor | x-ray diffraction | A, B | — | — |
| 4L7S | Kinase domain mutant of human itk in complex with an aminobenzothiazole inhibitor | x-ray diffraction | A, B | — | — |
| 4M0Y | Crystal structure of ITK in complex with compound 1… | x-ray diffraction | A | — | — |
| 4M0Y | Crystal structure of itk in complex with compound 1 [4… | x-ray diffraction | A | — | — |
| 4M0Z | Crystal structure of ITK in complex with compound 5… | x-ray diffraction | A | — | — |
| 4M0Z | Crystal structure of itk in complex with compound 5 {4… | x-ray diffraction | A | — | — |
| 4M12 | Crystal structure of ITK in complex with compound 7… | x-ray diffraction | A | — | — |
| 4M12 | Crystal structure of itk in complex with compound 7 [4… | x-ray diffraction | A | — | — |
| 4M13 | Crystal structure of ITK in complex with compound 8… | x-ray diffraction | A | — | — |
| 4M13 | Crystal structure of itk in complex with compound 8 [4… | x-ray diffraction | A | — | — |
| 4M14 | Crystal structure of ITK in complex with compound 9… | x-ray diffraction | A | — | — |
| 4M14 | Crystal structure of itk in complex with compound 9 [4… | x-ray diffraction | A | — | — |
| 4M15 | Crystal structure of ITK in complex with compound 9… | x-ray diffraction | A | — | — |
| 4M15 | Crystal structure of itk in complex with compound 9 [4… | x-ray diffraction | A | — | — |
| 4MF0 | ITK kinase domain in complex with benzothiazole inhibitor compound 12a… | x-ray diffraction | A, B | — | — |
| 4MF0 | Itk kinase domain in complex with benzothiazole inhibitor compound 12A… | x-ray diffraction | A, B | — | — |
| 4MF1 | ITK kinase domain in complex with benzothiazole inhibitor 12b… | x-ray diffraction | A, B | — | — |
| 4MF1 | Itk kinase domain in complex with benzothiazole inhibitor 12B (1S,2S)… | x-ray diffraction | A, B | — | — |
| 4PP9 | ITK kinase domain with compound 1 (N-[1-(3-CYANOBENZYL)-1H-PYRAZOL-4-YL]-2H-INDAZOLE-3-CARBOXAMIDE) | x-ray diffraction | A, B | — | — |
| 4PP9 | Itk kinase domain with compound 1 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4- yl]-2H-indazole-3-carboxamide) | x-ray diffraction | A, B | — | — |
13 records more on the page itself.
Experiment against prediction
- 3MJ1 chain A against the predicted model Q08881: TM-score 0.99, RMSD 0.56 Å
- 3MJ1 chain A against the predicted model Q08881: TM-score 0.99, RMSD 0.56 Å
- 1SNU chain B against the predicted model Q08881: TM-score 0.98, RMSD 0.90 Å
- 1SNU chain B against the predicted model Q08881: TM-score 0.98, RMSD 0.90 Å
- 1SM2 chain B against the predicted model Q08881: TM-score 0.97, RMSD 1.09 Å
- 1SM2 chain B against the predicted model Q08881: TM-score 0.97, RMSD 1.09 Å
- 1SM2 chain A against the predicted model Q08881: TM-score 0.97, RMSD 1.06 Å
- 1SM2 chain A against the predicted model Q08881: TM-score 0.97, RMSD 1.06 Å
- 3MJ2 chain A against the predicted model Q08881: TM-score 0.97, RMSD 1.14 Å
- 3MJ2 chain A against the predicted model Q08881: TM-score 0.97, RMSD 1.14 Å
Elsewhere
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