MolNFT v1 · #55773 · protein
Solution structure of the SH3 domain of human tyrosine-protein kinase ITK/TSK
2YUQ: “Solution structure of the SH3 domain of human tyrosine-protein kinase ITK/TSK”. Solution nmr, 1 pocket (best druggability 0.33). MolNFT v1 #55773 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2YUQ
- Type
- protein
- Length
- 85 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase ITK/TSK
- EC
- 2.7.10.2
- UniProt
- Q08881
- Pockets
- 1 · best druggability 0.33
Structure
solution nmr · 1 distinct chain · 0% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) | protein | 85 | 0% helix, 31% strand | Q08881 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.33 | 0.74 | 16 | empty |
Compared structures
- 2YUQ · Solution structure of the SH3 domain of human Tyrosine-protein kinase ITK/TSK · the same entry in another collection · chain A against A, TM-score 1.00
- Q08881 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q08881) · a predicted model of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08881
- Elsewhere: RCSB PDB 2YUQ · PDBe 2YUQ · UniProt Q08881
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