MolNFT v1 · #21868 · protein
Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain
1SNX · Tyrosine-protein kinase ITK/TSK: “Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain”. X-ray diffraction, 2 pockets (best druggability 0.64). MolNFT v1 #21868 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1SNX
- Type
- protein
- Length
- 490 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase ITK/TSK
- EC
- 2.7.1.112
- UniProt
- Q08881
- Pockets
- 2 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tyrosine-protein kinase ITK/TSK (EC 2.7.1.112) | protein | 245 | 36% helix, 14% strand | Q08881 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.64 | 0.81 | 36 | empty |
| 2 | 250 | 0.61 | 0.80 | 37 | empty |
Compared structures
- 1SNX · Crystal structure of apo interleukin-2 tyrosine kinase catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q08881 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ITK/TSK (Q08881) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08881
- Elsewhere: RCSB PDB 1SNX · PDBe 1SNX · UniProt Q08881
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