Research workbench
AlphaFold monomer V2.0 prediction for interleukin-12 subunit alpha (P43431)
Analyse AlphaFold monomer V2.0 prediction for interleukin-12 subunit alpha (P43431) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P43431
- Type
- protein
- Length
- 215 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9aD208242de9c7C25e2FbA3404A2bA0A5f6c2Eac
- Molecule
- Interleukin-12 subunit alpha
- UniProt
- P43431
- Pockets
- 2 · best druggability 0.41
Structure
1 distinct chain · 60% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-12 subunit alpha | protein | 215 | 60% helix, 0% strand | P43431 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.41 | 0.77 | 21 | empty |
| 2 | 77 | 0.36 | 0.76 | 16 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 8CR6 · mouse Interleukin-12 · an experimental structure of the same protein · chain A against B, TM-score 0.73
- 8ODZ · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against A, TM-score 0.70
- 8PB1 · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against A, TM-score 0.69
- 8OE0 · Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling… · an experimental structure of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43431
- Elsewhere: UniProt P43431 · AlphaFold DB P43431
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