Research workbench
AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase HST2 (P53686)
Analyse AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase HST2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P53686
- Type
- protein
- Length
- 357 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x2b96D8D371b665b98b97fC041377cCDaD440C537
- Molecule
- NAD-dependent protein deacetylase HST2
- UniProt
- P53686
- Pockets
- 2 · best druggability 0.78
Structure
1 distinct chain · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD-dependent protein deacetylase HST2 | protein | 357 | 44% helix, 13% strand | P53686 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1061 | 0.78 | 0.80 | 108 | empty |
| 2 | 95 | 0.33 | 0.73 | 22 | empty |
Compared structures
- 1Q1A · Structure of the yeast HST2 protein deacetylase in ternary complex with 2'-O-acetyl ADP… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 1Q1A · Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP… · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 1Q17 · Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP… · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 1Q17 · Structure of the yeast HST2 protein deacetylase in ternary complex with 2'-O-acetyl ADP… · an experimental structure of the same protein · chain A against B, TM-score 0.78
- 1SZD · Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 1SZD · Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 1SZC · Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 1SZC · Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… · an experimental structure of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53686
- Elsewhere: UniProt P53686 · AlphaFold DB P53686
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