UniProt P53686
P53686
P53686 (UniProt P53686): 23 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P53686
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 2
Structures
24 records of P53686 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Q14 | Structure and autoregulation of the yeast Hst2 homolog of Sir2 | x-ray diffraction | A | — | — |
| 1Q14 | Structure and autoregulation of the yeast HST2 homolog of SIR2 | x-ray diffraction | A | — | — |
| 1Q17 | Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | A, B, C | — | — |
| 1Q17 | Structure of the yeast HST2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | A, B, C | — | — |
| 1Q1A | Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | A | — | — |
| 1Q1A | Structure of the yeast HST2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and… | x-ray diffraction | A | — | — |
| 1SZC | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… | x-ray diffraction | A | — | — |
| 1SZC | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… | x-ray diffraction | A | — | — |
| 1SZD | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent Sir2… | x-ray diffraction | A | — | — |
| 1SZD | Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD+-dependent SIR2… | x-ray diffraction | A | — | — |
| 2OD2 | Crystal Structure of yHst2 I117F mutant bound to carba-NAD+ and an acetylated H4 peptide | x-ray diffraction | A | — | — |
| 2OD2 | Crystal structure of YHST2 I117F mutant bound to carba-NAD+ and an acetylated H4 peptide | x-ray diffraction | A | — | — |
| 2OD7 | Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide | x-ray diffraction | A | — | — |
| 2OD7 | Crystal structure of YHST2 bound to the intermediate analogue ADP-hpd, and and aceylated H4 peptide | x-ray diffraction | A | — | — |
| 2OD9 | Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes | x-ray diffraction | A | — | — |
| 2OD9 | Structural basis for nicotinamide inhibition and base exchange in SIR2 enzymes | x-ray diffraction | A | — | — |
| 2QQF | Hst2 bound to ADP-HPD and Acetylated histone H4 | x-ray diffraction | A | — | — |
| 2QQF | HST2 bound to ADP-hpd and acetylated histone H4 | x-ray diffraction | A | — | — |
| 2QQG | Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide | x-ray diffraction | A | — | — |
| 2QQG | HST2 bound to ADP-hpd, acetyllated histone H4 and nicotinamide | x-ray diffraction | A | — | — |
| 7F4E | Crystal structure of Hst2 in complex with H3K9bz peptide | x-ray diffraction | A | ZN | — |
| 7F4E | Crystal structure of HST2 in complex with H3K9BZ peptide | x-ray diffraction | A | ZN | — |
| 7F51 | Crystal structure of HST2 in complex with 2'-O-benzoyl ADP ribose | x-ray diffraction | A | ZN, BA7 | — |
| P53686 | AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase HST2 (P53686) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1Q1A chain A against the predicted model P53686: TM-score 0.99, RMSD 0.72 Å
- 1Q1A chain A against the predicted model P53686: TM-score 0.99, RMSD 0.72 Å
- 1Q17 chain A against the predicted model P53686: TM-score 0.95, RMSD 0.95 Å
- 1Q17 chain A against the predicted model P53686: TM-score 0.95, RMSD 0.95 Å
- 7F4E chain A against the predicted model P53686: TM-score 0.95, RMSD 1.93 Å
- 7F4E chain A against the predicted model P53686: TM-score 0.95, RMSD 1.93 Å
- 1Q17 chain B against the predicted model P53686: TM-score 0.94, RMSD 1.02 Å
- 1Q17 chain B against the predicted model P53686: TM-score 0.94, RMSD 1.02 Å
- 1SZD chain A against the predicted model P53686: TM-score 0.94, RMSD 1.99 Å
- 1SZD chain A against the predicted model P53686: TM-score 0.94, RMSD 1.99 Å
Elsewhere
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