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AlphaFold monomer V2.0 prediction for gasdermin-B (Q8TAX9)

Analyse AlphaFold monomer V2.0 prediction for gasdermin-B (Q8TAX9) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q8TAX9
Type: protein
Length: 411 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
Molecule: Gasdermin-B
UniProt: Q8TAX9
Pockets: 3 · best druggability 0.76

Structure

1 distinct chain · 40% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gasdermin-B	protein	411	40% helix, 17% strand	Q8TAX9

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	421	0.76	0.85	51	empty
2	217	0.73	0.88	29	empty
3	303	0.72	0.85	39	empty

Compared structures

8GTJ · Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex · an experimental structure of the same protein · chain A against A, TM-score 0.84
7WJQ · Crystal structure of GSDMB in complex with Ipah7.8 · an experimental structure of the same protein · chain A against B, TM-score 0.70
8EFP · CryoEM structure of GSDMB in complex with shigella IpaH7.8 · an experimental structure of the same protein · chain A against C, TM-score 0.66
8GTN · Cryo-EM structure of the gasdermin B pore · an experimental structure of the same protein · chain A against I, TM-score 0.45

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TAX9
Elsewhere: UniProt Q8TAX9 · AlphaFold DB Q8TAX9

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