UniProt Q8TAX9
Isoform 4 of Gasdermin-B (Q8TAX9)
Isoform 4 of Gasdermin-B (UniProt Q8TAX9): 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 82 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8TAX9
- Protein
- Isoform 4 of Gasdermin-B
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 82 · 6 records with a druggable one
Structures
10 records of Q8TAX9 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TIB | Gasdermin-B C-terminal domain containing the polymorphism residues Arg299:Ser306 fused to maltose… | x-ray diffraction | A, B | GLC, NA | 10 (best 0.72) |
| 5TIB | Gasdermin-B C-terminal domain containing the polymorphism residues ARG299:SER306 fused to maltose… | x-ray diffraction | A, B | GLC, NA | — |
| 5TJ2 | Gasdermin-B C-terminal domain containing the polymorphism residues GLY299:SER306 fused to maltose… | x-ray diffraction | A, B, C, D | GLC | — |
| 5TJ4 | Gasdermin-B C-terminal domain containing the polymorphism residues GLY299:PRO306 fused to maltose… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | GLC, NA | — |
| 7WJQ | Crystal structure of GSDMB in complex with Ipah7.8 | x-ray diffraction | B | — | 7 (best 0.69) |
| 8EFP | CryoEM structure of GSDMB in complex with shigella IpaH7.8 | electron microscopy | C | — | 9 (best 0.85) |
| 8ET2 | CryoEM structure of the GSDMB pore | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | 20 (best 0.88) |
| 8GTJ | Crystal structure of IpaH7.8-LRR and GSDMB isoform-4 complex | x-ray diffraction | A, C | — | 16 (best 0.82) |
| 8GTN | Cryo-EM structure of the gasdermin B pore | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y, Z, AA, BA | — | 20 (best 0.73) |
| Q8TAX9 | AlphaFold monomer V2.0 prediction for gasdermin-B (Q8TAX9) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8GTJ chain C against the predicted model Q8TAX9: TM-score 0.91, RMSD 2.09 Å
- 8GTJ chain A against the predicted model Q8TAX9: TM-score 0.90, RMSD 2.36 Å
- 7WJQ chain B against the predicted model Q8TAX9: TM-score 0.84, RMSD 2.96 Å
- 8GTN chain I against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain L against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain Q against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain Y against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain T against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain P against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
- 8GTN chain A against the predicted model Q8TAX9: TM-score 0.83, RMSD 1.72 Å
Elsewhere
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