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AlphaFold monomer V2.0 prediction for glypican-3 (Q8CFZ4)

Analyse AlphaFold monomer V2.0 prediction for glypican-3 (Q8CFZ4) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q8CFZ4
Type: protein
Length: 579 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x9188600a0FCa2914254C94299b1bd9721Bc4D500
Molecule: Glypican-3
UniProt: Q8CFZ4
Pockets: 7 · best druggability 0.60

Structure

1 distinct chain · 57% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glypican-3	protein	579	57% helix, 2% strand	Q8CFZ4

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	393	0.60	0.76	32	empty
2	129	0.57	0.83	23	empty
3	66	0.41	0.81	14	empty
4	52	0.39	0.81	13	empty
5	80	0.34	0.75	14	empty

Modifications

Observed in the structure: 7 disulfide (disulfide).

Compared structures

7ZA3 · GPC3-Unc5D octamer structure and role in cell migration · an experimental structure of the same protein · chain A against D, TM-score 0.59
7ZA2 · GPC3-Unc5D octamer structure and role in cell migration · an experimental structure of the same protein · chain A against D, TM-score 0.59
7ZAV · GPC3-Unc5D octamer structure and role in cell migration · an experimental structure of the same protein · chain A against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8CFZ4
Elsewhere: UniProt Q8CFZ4 · AlphaFold DB Q8CFZ4

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