UniProt Q8CFZ4
Glypican-3 (Q8CFZ4)
Glypican-3 (UniProt Q8CFZ4): 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8CFZ4
- Protein
- Glypican-3
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 36 · 2 records with a druggable one
Structures
4 records of Q8CFZ4 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7ZA2 | GPC3-Unc5D octamer structure and role in cell migration | x-ray diffraction | A, B, C, D | NAG | 18 (best 0.82) |
| 7ZA3 | GPC3-Unc5D octamer structure and role in cell migration | x-ray diffraction | A, B, C, D | NAG | 18 (best 0.81) |
| 7ZAV | GPC3-Unc5D octamer structure and role in cell migration | x-ray diffraction | A | NAG | — |
| Q8CFZ4 | AlphaFold monomer V2.0 prediction for glypican-3 (Q8CFZ4) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
Experiment against prediction
- 7ZA3 chain D against the predicted model Q8CFZ4: TM-score 0.97, RMSD 1.32 Å
- 7ZA2 chain D against the predicted model Q8CFZ4: TM-score 0.97, RMSD 1.34 Å
- 7ZA3 chain B against the predicted model Q8CFZ4: TM-score 0.96, RMSD 1.48 Å
- 7ZA3 chain C against the predicted model Q8CFZ4: TM-score 0.96, RMSD 1.47 Å
- 7ZA2 chain B against the predicted model Q8CFZ4: TM-score 0.95, RMSD 1.56 Å
- 7ZA2 chain C against the predicted model Q8CFZ4: TM-score 0.95, RMSD 1.55 Å
- 7ZA3 chain A against the predicted model Q8CFZ4: TM-score 0.95, RMSD 1.69 Å
- 7ZA2 chain A against the predicted model Q8CFZ4: TM-score 0.95, RMSD 1.73 Å
- 7ZAV chain A against the predicted model Q8CFZ4: TM-score 0.94, RMSD 1.79 Å
Elsewhere
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