Research workbench
AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 5 (P43026)
Analyse AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 5 (P43026) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P43026
- Type
- protein
- Length
- 501 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5404301550D726C7DCcB033FA4a78ff680cA7deD
- Molecule
- GROWTH/DIFFERENTIATION factor 5
- UniProt
- P43026
- Pockets
- 5 · best druggability 0.55
Structure
1 distinct chain · 18% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GROWTH/DIFFERENTIATION factor 5 | protein | 501 | 18% helix, 23% strand | P43026 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.55 | 0.85 | 24 | empty |
| 2 | 80 | 0.41 | 0.79 | 20 | empty |
| 3 | 77 | 0.41 | 0.79 | 16 | empty |
| 4 | 59 | 0.32 | 0.76 | 18 | empty |
| 5 | 69 | 0.28 | 0.73 | 15 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6Z3J · Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5… · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 6Z3J · Repulsive guidance molecule B (rgmb) in complex with growth differentiation factor 5… · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 6Z3M · Repulsive guidance molecule B (rgmb) in complex with growth differentiation factor 5… · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 6Z3M · Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5… · an experimental structure of the same protein · chain A against B, TM-score 0.21
- 3QB4 · Crystal structure of a TGF-beta ligand-receptor complex · an experimental structure of the same protein · chain A against C, TM-score 0.21
- 3QB4 · Crystal structure of a TGF-beta ligand-receptor complex · an experimental structure of the same protein · chain A against C, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43026
- Elsewhere: UniProt P43026 · AlphaFold DB P43026
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