UniProt P43026
Growth/differentiation factor 5 (P43026)
Growth/differentiation factor 5 (UniProt P43026): 23 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P43026
- Protein
- Growth/differentiation factor 5
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 30 · 2 records with a druggable one
Structures
24 records of P43026 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WAQ | Crystal structure of human Growth and Differentiation Factor 5 (GDF-5) | x-ray diffraction | A | — | — |
| 1WAQ | Crystal structure of human growth and differentiation factor 5 (gdf-5) | x-ray diffraction | A | — | — |
| 2BHK | Crystal structure of human growth and differentiation factor 5 (GDF5) | x-ray diffraction | A | — | — |
| 2BHK | Crystal structure of human growth and differentiation factor 5 (GDF5) | x-ray diffraction | A | — | — |
| 3EVS | Crystal structure of the GDF-5:BMP receptor IB complex. | x-ray diffraction | B | — | — |
| 3EVS | Crystal structure of the gdf-5:BMP receptor ib complex. | x-ray diffraction | B | — | — |
| 3QB4 | Crystal structure of a TGF-beta ligand-receptor complex | x-ray diffraction | A, C | — | — |
| 3QB4 | Crystal structure of a TGF-beta ligand-receptor complex | x-ray diffraction | A, C | — | — |
| 5HK5 | Structure of the Grem2-GDF5 Inhibitory Complex | x-ray diffraction | A, B, C, D | — | — |
| 5HK5 | Structure of the GREM2-GDF5 inhibitory complex | x-ray diffraction | A, B, C, D | — | — |
| 6Z3G | Repulsive guidance molecule a (rgma) in complex with growth differentiation factor 5 (GDF5) | x-ray diffraction | A | — | — |
| 6Z3H | Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5)… | x-ray diffraction | A | — | — |
| 6Z3H | Repulsive guidance molecule B (rgmb) in complex with growth differentiation factor 5 (GDF5)… | x-ray diffraction | A | — | — |
| 6Z3J | Repulsive guidance molecule B (rgmb) in complex with growth differentiation factor 5 (GDF5)… | x-ray diffraction | A, B | SO4, CL | — |
| 6Z3L | Repulsive Guidance Molecule C (RGMC, Hemojuvelin, HJV, HFE2) in complex with Growth Differentiation… | x-ray diffraction | A | — | — |
| 6Z3L | Repulsive guidance molecule C (rgmc, hemojuvelin, hjv, HFE2) in complex with growth differentiation… | x-ray diffraction | A | — | — |
| 6Z3M | Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) and… | x-ray diffraction | A, B, G, H, M, N | — | 14 (best 0.68) |
| 6Z3M | Repulsive guidance molecule B (rgmb) in complex with growth differentiation factor 5 (GDF5) and… | x-ray diffraction | A, B, G, H, M, N | — | — |
| 7ZJF | R399E, a mutated form of GDF5, for disease modification of osteoarthritis | x-ray diffraction | A, B | — | 2 (best 0.30) |
| 8BWL | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human… | x-ray diffraction | A, B | CA | 2 (best 0.42) |
| 8BWM | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human… | x-ray diffraction | A, B | CA | 3 (best 0.48) |
| 8BWN | Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human… | x-ray diffraction | A, B | CA | 3 (best 0.45) |
| 8E3G | BMP2/GDF5 heterodimer | x-ray diffraction | B, D | — | 6 (best 0.63) |
| P43026 | AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 5 (P43026) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3QB4 chain A against the predicted model P43026: TM-score 0.96, RMSD 0.81 Å
- 3QB4 chain A against the predicted model P43026: TM-score 0.96, RMSD 0.81 Å
- 6Z3M chain H against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3M chain H against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3J chain A against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3M chain M against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3M chain M against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3M chain A against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3M chain A against the predicted model P43026: TM-score 0.96, RMSD 0.78 Å
- 6Z3H chain A against the predicted model P43026: TM-score 0.96, RMSD 0.79 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.