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AlphaFold monomer V2.0 prediction for frizzled-3 (Q9NPG1)

Analyse AlphaFold monomer V2.0 prediction for frizzled-3 (Q9NPG1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

Accession: Q9NPG1
Type: protein
Length: 666 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0xE498A46d2e1B852A3eB35a100fb5E0a679D487dA
Molecule: Frizzled-3
UniProt: Q9NPG1
Pockets: 8 · best druggability 0.80

Structure

1 distinct chain · 49% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Frizzled-3	protein	666	49% helix, 3% strand	Q9NPG1

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.80	0.98	24	empty
2	65	0.70	0.96	18	empty
3	464	0.62	0.76	61	empty
4	280	0.59	0.77	31	empty
5	343	0.57	0.75	37	empty

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

8JHC · FZD3 in inactive state · an experimental structure of the same protein · chain A against R, TM-score 0.50
8JHI · FZD3-Gs complex · an experimental structure of the same protein · chain A against R, TM-score 0.46
8QW4 · FZD3 in complex with nanobody 9 · an experimental structure of the same protein · chain A against A, TM-score 0.45
8Q7O · Crystal structure of the FZD3 cysteine-rich domain in complex with a nanobody (14478) · an experimental structure of the same protein · chain A against D, TM-score 0.16

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NPG1
Elsewhere: UniProt Q9NPG1 · AlphaFold DB Q9NPG1

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