Research workbench
AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455)
Analyse AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- P22455
- Type
- protein
- Length
- 802 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x0002Ae91B0FDC26aE76c036F024CE258FeB6d459
- Molecule
- Fibroblast growth factor receptor 4
- UniProt
- P22455
- Pockets
- 7 · best druggability 0.78
Structure
1 distinct chain · 21% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fibroblast growth factor receptor 4 | protein | 802 | 21% helix, 24% strand | P22455 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 964 | 0.78 | 0.80 | 94 | empty |
| 2 | 321 | 0.58 | 0.76 | 36 | empty |
| 3 | 325 | 0.53 | 0.74 | 49 | empty |
| 4 | 153 | 0.47 | 0.77 | 28 | empty |
| 5 | 100 | 0.37 | 0.75 | 21 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7YC1 · Crystal structure of FGFR4 kinase domain with 10d · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7YC3 · Crystal structure of FGFR4 kinase domain with 10t · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCW · Crystal structure of FGFR4(V550L) kinase domain with 7v · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCW · Crystal structure of FGFR4(V550L) kinase domain with 7V · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7YBP · Crystal structure of FGFR4(V550L) kinase domain with 10z · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCX · Crystal structure of FGFR4(V550M) kinase domain with 7v · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCX · Crystal structure of FGFR4(V550M) kinase domain with 7V · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCT · Crystal structure of FGFR4 kinase domain with 7V · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7WCT · Crystal structure of FGFR4 kinase domain with 7v · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 7YBX · Crystal structure of FGFR4(V550M) kinase domain with 10z · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 8KH8 · Crystal structure of FGFR4(V550L) kinase domain with 8z · an experimental structure of the same protein · chain A against A, TM-score 0.34
- 8KH9 · Crystal structure of FGFR4(V550M) kinase domain with 8z · an experimental structure of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22455
- Elsewhere: UniProt P22455 · AlphaFold DB P22455
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