UniProt W5PFI3
Nicotinamide nucleotide transhydrogenase (W5PFI3)
Nicotinamide nucleotide transhydrogenase (UniProt W5PFI3): 5 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- W5PFI3
- Protein
- Nicotinamide nucleotide transhydrogenase
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 33 · 2 records with a druggable one
Structures
6 records of W5PFI3 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6QTI | Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down" conformation | electron microscopy | A, B | NAP, NAD, PC1, D12 | — |
| 6QUE | Structure of ovine transhydrogenase in the presence of NADP+ in a "single face-down" conformation | electron microscopy | A, B | NAP, NAD | — |
| 6QUE | Structure of ovine transhydrogenase in the presence of NADP+ in a "single face-down" conformation | electron microscopy | A, B | NAP, NAD | — |
| 6S59 | Structure of ovine transhydrogenase in the apo state | electron microscopy | A, B | PC1 | 20 (best 0.83) |
| 6S59 | Structure of ovine transhydrogenase in the apo state | electron microscopy | A, B | PC1 | — |
| W5PFI3 | AlphaFold monomer V2.0 prediction for NAD(P) transhydrogenase, mitochondrial (W5PFI3) | predicted | A | — | 13 (best 0.79) |
Ligands
Experiment against prediction
- 6S59 chain B against the predicted model W5PFI3: TM-score 0.98, RMSD 1.57 Å
- 6QTI chain A against the predicted model W5PFI3: TM-score 0.94, RMSD 2.75 Å
- 6S59 chain A against the predicted model W5PFI3: TM-score 0.94, RMSD 2.78 Å
- 6S59 chain A against the predicted model W5PFI3: TM-score 0.94, RMSD 2.78 Å
- 6QUE chain A against the predicted model W5PFI3: TM-score 0.89, RMSD 3.94 Å
- 6QUE chain A against the predicted model W5PFI3: TM-score 0.89, RMSD 3.94 Å
- 6QUE chain B against the predicted model W5PFI3: TM-score 0.86, RMSD 4.02 Å
- 6QUE chain B against the predicted model W5PFI3: TM-score 0.86, RMSD 4.02 Å
Elsewhere
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