MolNFT v1 · #266639 · protein
AlphaFold monomer V2.0 prediction for NAD(P) transhydrogenase, mitochondrial (W5PFI3)
W5PFI3: “AlphaFold monomer V2.0 prediction for NAD(P) transhydrogenase, mitochondrial (W5PFI3)”. 13 pockets (best druggability 0.79). MolNFT v1 #266639 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- W5PFI3
- Type
- protein
- Length
- 1,086 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x7c75F0f7d6d136A2b8D4C6C6e9b3D8a697949DF1
- Molecule
- NAD(P) transhydrogenase, mitochondrial
- UniProt
- W5PFI3
- Pockets
- 13 · best druggability 0.79
Structure
1 distinct chain · 54% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD(P) transhydrogenase, mitochondrial | protein | 1086 | 54% helix, 10% strand | W5PFI3 |
Pockets
13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.79 | 0.81 | 95 | empty |
| 2 | 476 | 0.73 | 0.82 | 47 | empty |
| 3 | 105 | 0.46 | 0.79 | 28 | empty |
| 4 | 124 | 0.46 | 0.77 | 18 | empty |
| 5 | 108 | 0.45 | 0.78 | 20 | empty |
Compared structures
- 6QTI · Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down"… · an experimental structure of the same protein · chain A against B, TM-score 0.95
- 6S59 · Structure of ovine transhydrogenase in the apo state · an experimental structure of the same protein · chain A against B, TM-score 0.93
- 6QTI · Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down"… · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 6S59 · Structure of ovine transhydrogenase in the apo state · an experimental structure of the same protein · chain A against A, TM-score 0.90
- 6QUE · Structure of ovine transhydrogenase in the presence of NADP+ in a "single face-down"… · an experimental structure of the same protein · chain A against A, TM-score 0.85
- 6QUE · Structure of ovine transhydrogenase in the presence of NADP+ in a "single face-down"… · an experimental structure of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt W5PFI3
- Elsewhere: UniProt W5PFI3 · AlphaFold DB W5PFI3
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