UniProt U3KQA6
Bromodomain-containing protein 2 (U3KQA6)
Bromodomain-containing protein 2 (UniProt U3KQA6): 11 experimental structures on GenesisL1, 5 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- U3KQA6
- Protein
- Bromodomain-containing protein 2
- Experimental structures
- 11
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 4 · 2 records with a druggable one
Structures
11 records of U3KQA6 in the MolNFT archive: 11 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7LAH | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to bromosporine | x-ray diffraction | A | BMF | 1 (best 0.49) |
| 7LAH | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to bromosporine | x-ray diffraction | A | BMF | — |
| 7LAI | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to BI2536 | x-ray diffraction | A | R78 | 1 (best 0.52) |
| 7LAI | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to BI2536 | x-ray diffraction | A | R78 | — |
| 7LAJ | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to Ro3280 | x-ray diffraction | A | 79C | — |
| 7LAJ | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to RO3280 | x-ray diffraction | A | 79C | — |
| 7LAK | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to volasertib | x-ray diffraction | A | IBI | 1 (best 0.47) |
| 7LAK | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to volasertib | x-ray diffraction | A | IBI | — |
| 7LAU | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to ERK5-IN-1 | x-ray diffraction | A | VYJ | — |
| 7LAU | Crystal structure of the first bromodomain (BD1) of human BRD2 bound to ERK5-in-1 | x-ray diffraction | A | VYJ | — |
| 8DNQ | BRD2-BD1 in complex with cyclic peptide 2.2B | x-ray diffraction | A, B | — | 1 (best 0.55) |
Ligands
- 79C · 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl) amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 2 records
- BMF · Bromosporine · in 2 records
- IBI · N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide · in 2 records
- R78 · 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide · in 2 records
- VYJ · 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one · in 2 records
Elsewhere
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