UniProt Q9Y657
Spindlin-1 (Q9Y657)
Spindlin-1 (UniProt Q9Y657): 29 experimental structures on GenesisL1, 10 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9Y657
- Protein
- Spindlin-1
- Experimental structures
- 29
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 19 · 1 record with a druggable one
Structures
29 records of Q9Y657 in the MolNFT archive: 29 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NS2 | Crystal Structure of Spindlin1 | x-ray diffraction | A, B | — | — |
| 2NS2 | Crystal structure of SPINDLIN1 | x-ray diffraction | A, B | — | — |
| 4H75 | Crystal structure of human Spindlin1 in complex with a histone H3K4(me3) peptide | x-ray diffraction | A | — | — |
| 4H75 | Crystal structure of human SPINDLIN1 in complex with a histone H3K4(ME3) peptide | x-ray diffraction | A | — | — |
| 4MZF | Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2a) peptide | x-ray diffraction | B | — | — |
| 4MZF | Crystal structure of human SPINDLIN1 bound to histone H3(K4ME3-R8ME2A) peptide | x-ray diffraction | B | — | — |
| 4MZG | Crystal structure of human Spindlin1 bound to histone H3K4me3 peptide | x-ray diffraction | B, D | — | — |
| 4MZG | Crystal structure of human SPINDLIN1 bound to histone H3K4ME3 peptide | x-ray diffraction | B, D | — | — |
| 4MZH | Crystal structure of human Spindlin1 bound to histone H3(K4me3-R8me2s) peptide | x-ray diffraction | A | — | — |
| 4MZH | Crystal structure of human SPINDLIN1 bound to histone H3(K4ME3-R8ME2S) peptide | x-ray diffraction | A | — | — |
| 5JSG | Crystal structure of SPINDLIN1 bound to compound EML405 | x-ray diffraction | A, B | — | — |
| 5JSJ | Crystal structure of Spindlin1 bound to compound EML631 | x-ray diffraction | A, B | 6PD, CL | — |
| 5JSJ | Crystal structure of SPINDLIN1 bound to compound EML631 | x-ray diffraction | A, B | — | — |
| 5Y5W | Crystal structure of human SPINDLIN1 in complex with a histone H4K20(ME3) peptide | x-ray diffraction | A, B, C, D | — | — |
| 6I8B | Crystal structure of SPINDLIN1 in complex with the inhibitor vinspinin | x-ray diffraction | B, E | H7T, PO4 | — |
| 6I8L | Crystal structure of SPINDLIN1 in complex with the inhibitor TD001851A | x-ray diffraction | B | H7Q | — |
| 6I8Y | Crystal structure of SPINDLIN1 in complex with the methyltransferase inhibitor A366 | x-ray diffraction | A | 2OD, NA | — |
| 6QPL | Crystal structure of Spindlin1 in complex with the inhibitor MS31 | x-ray diffraction | B | JC5, GLY, PO4 | 2 (best 0.46) |
| 6QPL | Crystal structure of SPINDLIN1 in complex with the inhibitor MS31 | x-ray diffraction | B | JC5, PO4 | — |
| 7BQZ | Crystal structure of SPINDLIN1 bound to H3(K4ME3-K9ME3) peptide | x-ray diffraction | A, C, E, G | — | — |
| 7BU9 | Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex | x-ray diffraction | A, C, E, G | — | 13 (best 0.53) |
| 7BU9 | Crystal structure of SPINDLIN1-H3(K4ME3-K9ME2) complex | x-ray diffraction | A, C, E, G | — | — |
| 7CNA | Crystal structure of SPINDLIN1/C11ORF84 complex bound to histone H3K4ME3K9ME3 peptide | — | — | — | |
| 7E9M | Crystal structure of SPINDLIN1 bound to spindoc DOCPEP3 | x-ray diffraction | A, C | — | — |
| 7EA1 | Crystal structure of SPINDLIN1 bound to spindoc DOCPEP2 | x-ray diffraction | A, C | — | — |
| 7OCB | Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B | x-ray diffraction | B | V88, PO4, CL, GLY, NA | 2 (best 0.46) |
| 7OCB | Crystal structure of SPINDLIN1 in complex with the inhibitor XY49-92B | x-ray diffraction | B | V88, PO4, CL, NA | — |
| 8GTX | Crystal Structure of human Spindlin1-HBx complex | x-ray diffraction | A | — | 2 (best 0.34) |
| Q9Y657 | AlphaFold monomer V2.0 prediction for spindlin-1 (Q9Y657) | — | — | — |
Ligands
- PO4 · Phosphate ion · in 5 records
- CL · Chloride ion · in 3 records
- NA · Sodium ion · in 3 records
- GLY · Glycine · in 2 records
- JC5 · [3-(aminomethyl)-5-[3-(1,3-dihydroisoindol-2-yl) propoxy]-4-methoxy-phenyl]methanamine · in 2 records
- V88 · 7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-2N-[2-(dimethylamino)ethyl]-6-methoxy-4N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine · in 2 records
- 2OD · 5'-methoxy-6'-[3-(pyrrolidin-1-yl) propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine · in 1 record
- 6PD · [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone · in 1 record
- H7Q · 5'-(cyclopropylmethoxy)-6'-[3-(1,3-dihydroisoindol-2-yl)propoxy]spiro[cyclopentane-1,3'-indole]-2'-amine · in 1 record
- H7T · 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone · in 1 record
Elsewhere
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