UniProt Q9Y5Y4
Prostaglandin D2 receptor 2 (Q9Y5Y4)
Prostaglandin D2 receptor 2 (UniProt Q9Y5Y4): 9 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 29 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y5Y4
- Protein
- Prostaglandin D2 receptor 2
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 29 · 7 records with a druggable one
Structures
10 records of Q9Y5Y4 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6D26 | Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant | x-ray diffraction | A | FSY, SO4, OLA | 4 (best 0.76) |
| 6D26 | Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipiprant | x-ray diffraction | A | FSY, SO4, OLA | — |
| 6D27 | Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471 | x-ray diffraction | A | SO4, FT4, OLA | 4 (best 0.78) |
| 6D27 | Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471 | x-ray diffraction | A | SO4, FT4, OLA | — |
| 7M8W | XFEL crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2 | x-ray diffraction | A | YSS, NA, SO4 | 4 (best 0.78) |
| 7M8W | Xfel crystal structure of the prostaglandin D2 receptor CRTH2 in complex with 15R-methyl-PGD2 | x-ray diffraction | A | YSS, NA, SO4 | — |
| 8XXU | Cryo-EM Structure of the Prostaglandin D2 Receptor 2 Coupled to G Protein | electron microscopy | A | A1D5Q | 5 (best 0.80) |
| 8XXV | Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein | electron microscopy | A | A1D5Q | 4 (best 0.81) |
| 9IYB | Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein | electron microscopy | A | A1D5Q | 5 (best 0.81) |
| Q9Y5Y4 | AlphaFold monomer V2.0 prediction for prostaglandin D2 receptor 2 (Q9Y5Y4) | predicted | A | — | 3 (best 0.77) |
Ligands
- SO4 · Sulfate ion · in 6 records
- OLA · Oleic acid · in 4 records
- A1D5Q · [(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate · in 3 records
- FSY · fevipiprant · in 2 records
- FT4 · [(3R)-3-{[(4-fluorophenyl)sulfonyl](methyl)amino}-1,2, 3,4-tetrahydro-9H-carbazol-9-yl]acetic acid · in 2 records
- NA · Sodium ion · in 2 records
- YSS · 15R-methyl-prostaglandin D2 · in 2 records
Experiment against prediction
- 9IYB chain A against the predicted model Q9Y5Y4: TM-score 0.95, RMSD 1.62 Å
- 8XXV chain A against the predicted model Q9Y5Y4: TM-score 0.94, RMSD 2.05 Å
- 8XXU chain A against the predicted model Q9Y5Y4: TM-score 0.89, RMSD 2.73 Å
- 7M8W chain A against the predicted model Q9Y5Y4: TM-score 0.72, RMSD 1.82 Å
- 7M8W chain A against the predicted model Q9Y5Y4: TM-score 0.72, RMSD 1.82 Å
- 6D26 chain A against the predicted model Q9Y5Y4: TM-score 0.70, RMSD 1.70 Å
- 6D26 chain A against the predicted model Q9Y5Y4: TM-score 0.70, RMSD 1.70 Å
- 6D27 chain A against the predicted model Q9Y5Y4: TM-score 0.70, RMSD 1.80 Å
- 6D27 chain A against the predicted model Q9Y5Y4: TM-score 0.70, RMSD 1.80 Å
Elsewhere
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