UniProt Q9Y5U4
Insulin-induced gene 2 protein (Q9Y5U4)
Insulin-induced gene 2 protein (UniProt Q9Y5U4): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9Y5U4
- Protein
- Insulin-induced gene 2 protein
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 2 records with a druggable one
Structures
7 records of Q9Y5U4 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4J82 | Crystal structure of beta'-COP/Insig-2 complex | x-ray diffraction | C, D | — | — |
| 4J82 | Crystal structure of beta'-COP/INSIG-2 complex | x-ray diffraction | C, D | — | — |
| 6M49 | cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol. | electron microscopy | A | HC3 | 4 (best 0.80) |
| 6M49 | Cryo-EM structure of SCAP/INSIG complex in the present of 25-hydroxyl cholesterol. | electron microscopy | A | HC3 | — |
| 7ETW | Cryo-EM structure of Scap/Insig complex in the present of digitonin. | electron microscopy | A | AJP | 7 (best 0.80) |
| 7ETW | Cryo-EM structure of SCAP/INSIG complex in the present of digitonin. | electron microscopy | A | AJP | — |
| Q9Y5U4 | AlphaFold monomer V2.0 prediction for insulin-induced gene 2 protein (Q9Y5U4) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6M49 chain A against the predicted model Q9Y5U4: TM-score 0.90, RMSD 2.08 Å
- 6M49 chain A against the predicted model Q9Y5U4: TM-score 0.90, RMSD 2.08 Å
- 7ETW chain A against the predicted model Q9Y5U4: TM-score 0.85, RMSD 2.50 Å
- 7ETW chain A against the predicted model Q9Y5U4: TM-score 0.85, RMSD 2.50 Å
- 4J82 chain C against the predicted model Q9Y5U4: TM-score 0.57, RMSD 0.60 Å
- 4J82 chain C against the predicted model Q9Y5U4: TM-score 0.57, RMSD 0.60 Å
Elsewhere
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