UniProt Q9Y4X5
E3 ubiquitin-protein ligase ARIH1 (Q9Y4X5)
E3 ubiquitin-protein ligase ARIH1 (UniProt Q9Y4X5), EC 2.3.2.-, 2.3.2.31: 20 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9Y4X5
- Protein
- E3 ubiquitin-protein ligase ARIH1
- EC
- 2.3.2.-, 2.3.2.31, 6.3.2.19
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 47 · 5 records with a druggable one
Structures
21 records of Q9Y4X5 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WD2 | Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif | solution nmr | A | ZN | 1 (best 0.49) |
| 1WD2 | Solution structure of the C-terminal ring from a ring-ibr-ring (triad) motif | solution nmr | A | — | — |
| 2M9Y | Solution Structure of the Catalytic Domain of HHARI | solution nmr | A | — | — |
| 2M9Y | Solution structure of the catalytic domain of hhari | solution nmr | A | — | — |
| 4KBL | Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and… | x-ray diffraction | A, B | — | — |
| 4KBL | Structure of hhari, a ring-ibr-ring ubiquitin ligase: autoinhibition of an ariadne-family E3 and… | x-ray diffraction | A, B | — | — |
| 4KC9 | Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and… | x-ray diffraction | A | — | — |
| 4KC9 | Structure of hhari, a ring-ibr-ring ubiquitin ligase: autoinhibition of an ariadne-family E3 and… | x-ray diffraction | A | — | — |
| 5TTE | Crystal Structure of an RBR E3 ubiquitin ligase in complex with an E2-Ub thioester intermediate… | x-ray diffraction | B | ZN | 8 (best 0.72) |
| 5TTE | Crystal structure of an rbr E3 ubiquitin ligase in complex with an E2- ub thioester intermediate… | x-ray diffraction | B | ZN | — |
| 5UDH | HHARI/ARIH1-UBCH7~Ubiquitin | x-ray diffraction | A, B | ZN | 12 (best 0.61) |
| 5UDH | HHARI/ARIH1-UBCH7~UBIQUITIN | x-ray diffraction | A, B | ZN | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | H | ZN, SY8 | — |
| 7B5L | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | H | ZN, SY8 | — |
| 7B5M | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | H | ZN | 7 (best 0.65) |
| 7B5M | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | H | ZN | — |
| 7B5N | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly… | electron microscopy | H | ZN, SY8 | 13 (best 0.81) |
| 7B5N | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly… | electron microscopy | H | ZN, SY8 | — |
| 7B5S | Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1… | electron microscopy | H | ZN | 6 (best 0.66) |
| 7B5S | Ubiquitin ligation to F-box protein substrates by scf-rbr E3-E3 super- assembly: CUL1-RBX1-ARIH1… | electron microscopy | H | ZN | — |
| Q9Y4X5 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase ARIH1 (Q9Y4X5) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5UDH chain B against the predicted model Q9Y4X5: TM-score 0.97, RMSD 1.28 Å
- 5UDH chain B against the predicted model Q9Y4X5: TM-score 0.97, RMSD 1.28 Å
- 5TTE chain B against the predicted model Q9Y4X5: TM-score 0.97, RMSD 1.61 Å
- 5TTE chain B against the predicted model Q9Y4X5: TM-score 0.97, RMSD 1.61 Å
- 5UDH chain A against the predicted model Q9Y4X5: TM-score 0.95, RMSD 1.79 Å
- 5UDH chain A against the predicted model Q9Y4X5: TM-score 0.95, RMSD 1.79 Å
- 4KC9 chain A against the predicted model Q9Y4X5: TM-score 0.92, RMSD 2.29 Å
- 4KC9 chain A against the predicted model Q9Y4X5: TM-score 0.92, RMSD 2.29 Å
- 7B5S chain H against the predicted model Q9Y4X5: TM-score 0.87, RMSD 2.26 Å
- 7B5S chain H against the predicted model Q9Y4X5: TM-score 0.87, RMSD 2.26 Å
Elsewhere
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