UniProt Q9Y3D5
28S ribosomal protein S18c, mitochondrial (Q9Y3D5)
28S ribosomal protein S18c, mitochondrial (UniProt Q9Y3D5): 47 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9Y3D5
- Protein
- 28S ribosomal protein S18c, mitochondrial
- Experimental structures
- 47
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 40 · 25 records with a druggable one
Structures
48 records of Q9Y3D5 in the MolNFT archive: 47 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J9M | Structure of the human mitochondrial ribosome (class 1) | electron microscopy | AP | — | — |
| 6NU2 | Structural insights into unique features of the human mitochondrial ribosome recycling | electron microscopy | AP | ZN | — |
| 6NU3 | Structural insights into unique features of the human mitochondrial ribosome recycling | electron microscopy | AP | ZN | — |
| 6RW4 | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF3 | electron microscopy | P | FES | 2 (best 0.84) |
| 6RW5 | Structure of human mitochondrial 28S ribosome in complex with mitochondrial IF2 and IF3 | electron microscopy | P | FES | 1 (best 0.84) |
| 6VLZ | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI) | electron microscopy | AP | ZN | 1 (best 0.87) |
| 6VMI | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII) | electron microscopy | AP | ZN | — |
| 6ZM5 | Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide | electron microscopy | AP | FES | — |
| 6ZM6 | Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA | electron microscopy | AP | FES | — |
| 6ZS9 | Human mitochondrial ribosome in complex with ribosome recycling factor | electron microscopy | AP | ZN | — |
| 6ZSA | Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA | electron microscopy | AP | ZN | 1 (best 0.85) |
| 6ZSB | Human mitochondrial ribosome in complex with mRNA and P-site tRNA | electron microscopy | AP | ZN | — |
| 6ZSC | Human mitochondrial ribosome in complex with E-site tRNA | electron microscopy | AP | ZN | — |
| 6ZSD | Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA | electron microscopy | AP | ZN | 1 (best 0.86) |
| 6ZSE | Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA | electron microscopy | AP | ZN | — |
| 6ZSG | Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA | electron microscopy | AP | ZN | — |
| 7A5F | Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs | electron microscopy | P6 | ZN | — |
| 7A5G | Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA | electron microscopy | P6 | ZN | 1 (best 0.83) |
| 7A5I | Structure of the human mitoribosome with A- P-and E-site mt-tRNAs | electron microscopy | P6 | ZN | 1 (best 0.85) |
| 7A5K | Structure of the human mitoribosome in the post translocation state bound to mtEF-G1 | electron microscopy | P6 | ZN | 1 (best 0.83) |
| 7L08 | Cryo-EM structure of the human 55S mitoribosome-RRFmt complex. | electron microscopy | AP | ZN | — |
| 7OG4 | Human mitochondrial ribosome in complex with P/E-tRNA | electron microscopy | AP | ZN | — |
| 7PNX | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | P | FES | 2 (best 0.84) |
| 7PNY | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | P | FES | 3 (best 0.80) |
| 7PNZ | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | P | FES | 2 (best 0.80) |
| 7PO0 | Assembly intermediate of human mitochondrial ribosome small subunit without mS37 in complex with… | electron microscopy | P | FES | 3 (best 0.84) |
| 7PO1 | Initiation complex of human mitochondrial ribosome small subunit with IF3 | electron microscopy | P | FES | 1 (best 0.81) |
| 7PO2 | Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA | electron microscopy | P | FES | 2 (best 0.80) |
| 7PO3 | Human mitochondrial ribosome small subunit | electron microscopy | P | FES | 2 (best 0.87) |
| 7QI4 | Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA) | electron microscopy | AP | FES | — |
| 7QI5 | Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution | electron microscopy | AP | FES | — |
| 7QI6 | Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution | electron microscopy | AP | FES | — |
| 8CSP | Human mitochondrial small subunit assembly intermediate (State A) | electron microscopy | P | FES | — |
| 8CSQ | Human mitochondrial small subunit assembly intermediate (State B) | electron microscopy | P | FES | 1 (best 0.72) |
| 8CSR | Human mitochondrial small subunit assembly intermediate (State C) | electron microscopy | P | FES | 1 (best 0.82) |
| 8CSS | Human mitochondrial small subunit assembly intermediate (State D) | electron microscopy | P | FES | 3 (best 0.82) |
| 8CST | Human mitochondrial small subunit assembly intermediate (State E) | electron microscopy | P | FES | — |
| 8CSU | Human mitochondrial small subunit assembly intermediate (State C*) | electron microscopy | P | FES | 2 (best 0.81) |
| 8K2A | Cryo-EM structure of the human 55S mitoribosome with Tigecycline | electron microscopy | ST | ZN | — |
| 8OIR | 55S human mitochondrial ribosome with mtRF1 and P-site tRNA | electron microscopy | AP | FS2 | — |
| 8OIS | 28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA | electron microscopy | AP | FS2 | 1 (best 0.82) |
| 8QRK | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 1 | electron microscopy | P | FES | 2 (best 0.84) |
| 8QRL | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 2 | electron microscopy | P | FES | 2 (best 0.81) |
| 8QRM | mt-SSU assembly intermediate in GTPBP8 knock-out cells, state 3 | electron microscopy | P | FES | 2 (best 0.84) |
| 8QRN | mt-SSU in GTPBP8 knock-out cells, state 4 | electron microscopy | P | FES | 1 (best 0.84) |
| 8XT0 | Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline | electron microscopy | ST | ZN | — |
| 8XT2 | Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline | electron microscopy | ST | ZN | — |
| Q9Y3D5 | AlphaFold monomer V2.0 prediction for 28S ribosomal protein S18C, mitochondrial (Q9Y3D5) | predicted | A | — | 1 (best 0.50) |
Ligands
Experiment against prediction
- 8XT2 chain ST against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.82 Å
- 8XT0 chain ST against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.83 Å
- 8K2A chain ST against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.85 Å
- 8QRK chain P against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.93 Å
- 8QRN chain P against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.93 Å
- 6RW5 chain P against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.93 Å
- 8QRM chain P against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.93 Å
- 6RW4 chain P against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.92 Å
- 7A5F chain P6 against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.96 Å
- 7QI4 chain AP against the predicted model Q9Y3D5: TM-score 0.96, RMSD 0.99 Å
Elsewhere
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