UniProt Q9UMR2
ATP-dependent RNA helicase DDX19B (Q9UMR2)
ATP-dependent RNA helicase DDX19B (UniProt Q9UMR2), EC 3.6.4.13: 18 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9UMR2
- Protein
- ATP-dependent RNA helicase DDX19B
- EC
- 3.6.4.13
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 36 · 3 records with a druggable one
Structures
19 records of Q9UMR2 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3EWS | Human DEAD-box RNA-helicase DDX19 in complex with ADP | x-ray diffraction | A, B | — | — |
| 3EWS | Human dead-box RNA-helicase DDX19 in complex with ADP | x-ray diffraction | A, B | — | — |
| 3FHC | Crystal structure of human Dbp5 in complex with Nup214 | x-ray diffraction | B | — | — |
| 3FHC | Crystal structure of human DBP5 in complex with NUP214 | x-ray diffraction | B | — | — |
| 3FHT | Crystal structure of human Dbp5 in complex with AMPPNP and RNA | x-ray diffraction | A, B | — | — |
| 3FHT | Crystal structure of human DBP5 in complex with amppnp and RNA | x-ray diffraction | A, B | — | — |
| 3FMO | Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 | x-ray diffraction | B | — | — |
| 3FMO | Crystal structure of the nucleoporin NUP214 in complex with the dead- box helicase DDX19 | x-ray diffraction | B | — | — |
| 3FMP | Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 | x-ray diffraction | B, D | — | — |
| 3FMP | Crystal structure of the nucleoporin NUP214 in complex with the dead- box helicase DDX19 | x-ray diffraction | B, D | — | — |
| 3G0H | Human dead-box RNA helicase DDX19, in complex with an ATP-analogue and RNA | x-ray diffraction | A | — | — |
| 3G0H | Human dead-box RNA helicase DDX19, in complex with an ATP-analogue and RNA | x-ray diffraction | A | — | — |
| 6B4I | Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(ADP) complex | x-ray diffraction | E, F | ADP, PO4 | 14 (best 0.83) |
| 6B4I | Crystal structure of human GLE1 ctd-NUP42 gbm-DDX19B(ADP) complex | x-ray diffraction | E, F | ADP, PO4 | — |
| 6B4J | Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(AMPPNP) complex | x-ray diffraction | E, F | PO4, MG, ANP | 11 (best 0.82) |
| 6B4J | Crystal structure of human GLE1 ctd-NUP42 gbm-DDX19B(AMPPNP) complex | x-ray diffraction | E, F | PO4, MG, ANP | — |
| 6B4K | Crystal structure of human DDX19B(AMPPNP) | x-ray diffraction | A, B | MG, ANP | 11 (best 0.78) |
| 6B4K | Crystal structure of human DDX19B(AMPPNP) | x-ray diffraction | A, B | MG, ANP | — |
| Q9UMR2 | AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DDX19B (Q9UMR2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3FMP chain D against the predicted model Q9UMR2: TM-score 0.99, RMSD 0.68 Å
- 3FMP chain D against the predicted model Q9UMR2: TM-score 0.99, RMSD 0.68 Å
- 3FMP chain B against the predicted model Q9UMR2: TM-score 0.99, RMSD 0.68 Å
- 3FMP chain B against the predicted model Q9UMR2: TM-score 0.99, RMSD 0.68 Å
- 3FMO chain B against the predicted model Q9UMR2: TM-score 0.98, RMSD 0.91 Å
- 3FMO chain B against the predicted model Q9UMR2: TM-score 0.98, RMSD 0.91 Å
- 3FHC chain B against the predicted model Q9UMR2: TM-score 0.97, RMSD 1.25 Å
- 3FHC chain B against the predicted model Q9UMR2: TM-score 0.97, RMSD 1.25 Å
- 6B4J chain E against the predicted model Q9UMR2: TM-score 0.91, RMSD 2.32 Å
- 6B4J chain E against the predicted model Q9UMR2: TM-score 0.91, RMSD 2.32 Å
Elsewhere
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