UniProt Q9UKS7
Zinc finger protein Helios (Q9UKS7)
Zinc finger protein Helios (UniProt Q9UKS7): 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UKS7
- Protein
- Zinc finger protein Helios
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 2 records with a druggable one
Structures
4 records of Q9UKS7 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7LPS | Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2) | x-ray diffraction | C, F, I, L | RN9, ZN | — |
| 7LPS | Crystal structure of DDB1-crbn-ALV1 complex bound to helios (IKZF2 ZF2) | x-ray diffraction | C, F, I, L | RN9, ZN | — |
| 8DEY | Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue DKY709 | x-ray diffraction | C, F | LWK, ZN | 3 (best 0.75) |
| Q9UKS7 | AlphaFold monomer V2.0 prediction for zinc finger protein helios (Q9UKS7) | predicted | A | — | 4 (best 0.53) |
Ligands
- ZN · Zinc ion · in 3 records
- RN9 · 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide · in 2 records
- LWK · (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione · in 1 record
Experiment against prediction
- 7LPS chain F against the predicted model Q9UKS7: TM-score 0.90, RMSD 0.38 Å
- 7LPS chain F against the predicted model Q9UKS7: TM-score 0.90, RMSD 0.38 Å
- 7LPS chain C against the predicted model Q9UKS7: TM-score 0.89, RMSD 0.52 Å
- 7LPS chain C against the predicted model Q9UKS7: TM-score 0.89, RMSD 0.52 Å
- 8DEY chain C against the predicted model Q9UKS7: TM-score 0.57, RMSD 2.95 Å
Elsewhere
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