GL1X · GenesisL1 explorer

Ligand · LWK

LWK · (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione

LWK, (3S)-3-[5-(1-benzylpiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione (C25 H27 N3 O3, 417.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues…

Component
LWK
Formula
C25 H27 N3 O3
Class
ligand
Structures
2
PDB entries
2

Binding sites

LWK in 2 structures; the first of them:

  • 7U8F · Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue… · LWK A502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 9 more
  • 8DEY · Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2,3) and the molecular glue… · LWK A502 · binds VAL350, ASN351, PRO352, HIS353, GLU377, HIS378, SER379, TRP380 and 9 more

Residues it binds most

HIS 3, TRP 3, ASN 3, CYS 3, GLN 3, GLU 3, GLY 3, PHE 3, PRO 3, SER 3 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SO4 · Sulfate ion
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid

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