UniProt Q9UKL4
Gap junction delta-2 protein (Q9UKL4)
Gap junction delta-2 protein (UniProt Q9UKL4): 20 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 340 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UKL4
- Protein
- Gap junction delta-2 protein
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 340 · 17 records with a druggable one
Structures
21 records of Q9UKL4 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N6A | NMR structure of a human calmodulin/connexin-36 peptide hybrid | solution nmr | A | — | — |
| 2N6A | NMR structure of a human CALMODULIN/CONNEXIN-36 peptide hybrid | solution nmr | A | — | — |
| 7XKI | Human Cx36/GJD2 (N-terminal deletion BRIL-fused mutant) gap junction channel in soybean lipids (D6… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3 | 20 (best 0.65) |
| 7XKK | Human Cx36/GJD2 gap junction channel in detergents | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.66) |
| 7XKT | Human Cx36/GJD2 (BRIL-fused mutant) gap junction channel in detergents at 2.2 Angstroms resolution | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3, Y01, LHG | 20 (best 0.72) |
| 7XL8 | Human Cx36/GJD2 (N-terminal deletion mutant) gap junction channel in soybean lipids (D6 symmetry) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3 | 20 (best 0.60) |
| 7XNH | Human Cx36/GJD2 gap junction channel with pore-lining N-terminal helices in soybean lipids | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3 | — |
| 7XNV | Structurally hetero-junctional human Cx36/GJD2 gap junction channel in soybean lipids (C6 symmetry) | electron microscopy | G, H, I, J, K, L, A, B, C, D, E, F | MC3 | 20 (best 0.73) |
| 8HKP | Structurally hetero-junctional human Cx36/GJD2 gap junction channel in detergents (C6 symmetry) | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | AV0 | 20 (best 0.76) |
| 8IYG | Human neuronal gap junction channel connexin 36 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | Y01 | 20 (best 0.72) |
| 8QOJ | human connexin-36 gap junction channel in complex with mefloquine | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | YMZ | 20 (best 0.62) |
| 8R7P | human connexin-36 gap junction channel | electron microscopy | L, A, B, C, D, E, F, G, H, I, J, K | — | 20 (best 0.62) |
| 8R7Q | human connexin-36 gap junction channel in complex with quinine | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | QI9 | 20 (best 0.63) |
| 8R7R | human connexin36 gap junction channel in complex with quinidine | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | QDN | 20 (best 0.64) |
| 8XGD | Human Cx36/GJD2 gap junction channel with pore-lining N-terminal helices in porcine brain lipids. | electron microscopy | A, F, G, B, C, D, E, H, I, J, K, L | MC3, Y01 | 20 (best 0.76) |
| 8XGF | Human Cx36/GJD2 gap junction channel in complex with arachidonic acid. | electron microscopy | A, J, B, C, D, E, F, G, H, I, K, L | MC3, ACD | 20 (best 0.68) |
| 8XGG | Human Cx36/GJD2 gap junction channel in complex with 1-hexanol. | electron microscopy | A, C, B, D, E, F, G, H, I, J, K, L | MC3, HE2 | 20 (best 0.70) |
| 8XGJ | Human Cx36/GJD2 gap junction channel in complex with mefloquine. | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | YMZ, MC3 | 20 (best 0.70) |
| 8XH8 | Human Cx36/GJD2 (Ala14-deleted mutant) gap junction channel in porcine brain lipids | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3 | 20 (best 0.72) |
| 8XH9 | Human Cx36/GJD2 (Ala14 deletion mutant) gap junction channel prepared with mefloquine, showing no… | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MC3 | 20 (best 0.72) |
| Q9UKL4 | AlphaFold monomer V2.0 prediction for gap junction delta-2 protein (Q9UKL4) | predicted | A | — | — |
Ligands
- MC3 · 1,2-dimyristoyl-rac-glycero-3-phosphocholine · in 11 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- YMZ · (11R,12S)- Mefloquine · in 2 records
- ACD · Arachidonic acid · in 1 record
- AV0 · 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 1 record
- HE2 · Hexan-1-ol · in 1 record
- LHG · 1,2-dipalmitoyl-phosphatidyl-glycerole · in 1 record
- QDN · Quinidine · in 1 record
- QI9 · Quinine · in 1 record
Experiment against prediction
- 7XL8 chain C against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain K against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain E against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain G against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain B against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain A against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain I against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain L against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain J against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
- 7XL8 chain H against the predicted model Q9UKL4: TM-score 0.95, RMSD 1.28 Å
Elsewhere
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