UniProt Q9UJQ4
Sal-like protein 4 (Q9UJQ4)
Sal-like protein 4 (UniProt Q9UJQ4): 13 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UJQ4
- Protein
- Sal-like protein 4
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 43 · 11 records with a druggable one
Structures
14 records of Q9UJQ4 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UML | Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide… | x-ray diffraction | E | Y70, ZN | 3 (best 0.56) |
| 6UML | Structural basis for thalidomide teratogenicity revealed by the cereblon-DDB1-SALL4-pomalidomide… | x-ray diffraction | E | Y70, ZN | 3 (best 0.56) |
| 7BQU | Cereblon in complex with SALL4 and (S)-thalidomide | x-ray diffraction | B | EF2, ZN | 2 (best 0.57) |
| 7BQU | Cereblon in complex with SALL4 and (S)-thalidomide | x-ray diffraction | B | EF2, ZN | — |
| 7BQV | Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide | x-ray diffraction | B | F4U, ZN, SO4 | 2 (best 0.54) |
| 7BQV | Cereblon in complex with SALL4 and (S)-5-hydroxythalidomide | x-ray diffraction | B | ZN, SO4 | — |
| 7Y3I | Structure of DNA bound SALL4 | x-ray diffraction | A, B, C, D | ZN | 4 (best 0.65) |
| 7Y3K | Structure of SALL4 ZFC4 bound with 16 bp AT-rich dsDNA | x-ray diffraction | A, B | ZN | 3 (best 0.63) |
| 7Y3M | Structure of SALL4 ZFC1 bound with 16 bp AT-rich dsDNA | x-ray diffraction | B, C, A, F, J, I | ZN | 10 (best 0.71) |
| 8CUC | Crystal structure analysis of SALL4 zinc finger domain in complex with DNA | x-ray diffraction | E, F, G, H | ZN | 3 (best 0.67) |
| 8U15 | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220 | x-ray diffraction | C, F | 8W7, SO4, ZN | 5 (best 0.74) |
| 8U16 | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide | x-ray diffraction | C, F | Y70, ZN | 4 (best 0.71) |
| 8U17 | The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide | x-ray diffraction | C, F | Y70, ZN | 3 (best 0.76) |
| Q9UJQ4 | AlphaFold monomer V2.0 prediction for sal-like protein 4 (Q9UJQ4) | predicted | A | — | 1 (best 0.30) |
Ligands
- ZN · Zinc ion · in 13 records
- Y70 · S-Pomalidomide · in 4 records
- SO4 · Sulfate ion · in 3 records
- EF2 · S-Thalidomide · in 2 records
- 8W7 · (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione · in 1 record
- F4U · 2-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-5-oxidanyl-isoindole-1,3-dione · in 1 record
Experiment against prediction
- 7Y3I chain B against the predicted model Q9UJQ4: TM-score 0.95, RMSD 0.61 Å
- 7Y3K chain A against the predicted model Q9UJQ4: TM-score 0.95, RMSD 0.62 Å
- 8CUC chain G against the predicted model Q9UJQ4: TM-score 0.94, RMSD 0.69 Å
- 7Y3K chain B against the predicted model Q9UJQ4: TM-score 0.93, RMSD 0.72 Å
- 7Y3M chain J against the predicted model Q9UJQ4: TM-score 0.91, RMSD 0.79 Å
- 7Y3M chain F against the predicted model Q9UJQ4: TM-score 0.91, RMSD 0.93 Å
- 8CUC chain E against the predicted model Q9UJQ4: TM-score 0.90, RMSD 0.32 Å
- 7Y3I chain C against the predicted model Q9UJQ4: TM-score 0.90, RMSD 0.35 Å
- 7Y3I chain A against the predicted model Q9UJQ4: TM-score 0.90, RMSD 0.88 Å
- 7Y3M chain B against the predicted model Q9UJQ4: TM-score 0.90, RMSD 0.97 Å
Elsewhere
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