UniProt Q9UHE8

Metalloreductase STEAP1 (Q9UHE8)

Metalloreductase STEAP1 (UniProt Q9UHE8), EC 1.16.1.-: 3 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q9UHE8
Protein: Metalloreductase STEAP1
EC: 1.16.1.-
Experimental structures: 3
Predicted models: 1
Ligands: 4
Pockets: 27 · 3 records with a druggable one

Structures

4 records of Q9UHE8 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
6Y9B	Cryo-EM structure of trimeric human STEAP1 bound to three Fab120.545 fragments	electron microscopy	C, A, B	HEM, XP4	12 (best 0.86)
6Y9B	Cryo-EM structure of trimeric human STEAP1 bound to three FAB120.545 fragments	electron microscopy	C, A, B	HEM, XP4	—
8UCD	Cryo-EM structure of human STEAP1 in complex with AMG 509 Fab	electron microscopy	A, B, C	LBN, FAD, HEM	13 (best 0.87)
Q9UHE8	AlphaFold monomer V2.0 prediction for metalloreductase STEAP1 (Q9UHE8)	predicted	A	—	2 (best 0.73)

Ligands

HEM · Protoporphyrin IX containing Fe · in 3 records
XP4 · 1,2-dimyristoyl-sn-glycero-3-phosphate · in 2 records
FAD · Flavin-adenine dinucleotide · in 1 record
LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · in 1 record

Experiment against prediction

6Y9B chain C against the predicted model Q9UHE8: TM-score 0.99, RMSD 0.43 Å
6Y9B chain C against the predicted model Q9UHE8: TM-score 0.99, RMSD 0.43 Å
8UCD chain B against the predicted model Q9UHE8: TM-score 0.98, RMSD 0.93 Å
8UCD chain A against the predicted model Q9UHE8: TM-score 0.97, RMSD 0.94 Å
8UCD chain C against the predicted model Q9UHE8: TM-score 0.97, RMSD 0.96 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.