UniProt Q9UGN5
Poly [ADP-ribose] polymerase 2 (Q9UGN5)
Poly [ADP-ribose] polymerase 2 (UniProt Q9UGN5), EC 2.4.2.-, 2.4.2.30: 26 experimental structures on GenesisL1, 2 ligands bound, 5 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9UGN5
- Protein
- Poly [ADP-ribose] polymerase 2
- EC
- 2.4.2.-, 2.4.2.30
- Experimental structures
- 26
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 5 · 1 record with a druggable one
Structures
26 records of Q9UGN5 in the MolNFT archive: 26 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KCZ | Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B | — | — |
| 3KCZ | Human POLY(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor… | x-ray diffraction | A, B | — | — |
| 3KJD | Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor ABT-888 | x-ray diffraction | A, B | — | — |
| 3KJD | Human POLY(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 | x-ray diffraction | A, B | — | — |
| 4PJV | Structure of PARP2 catalytic domain bound to inhibitor BMN 673 | x-ray diffraction | A, B | — | — |
| 4PJV | Structure of PARP2 catalytic domain bound to inhibitor bmn 673 | x-ray diffraction | A, B | — | — |
| 4TVJ | Human ARTD2 (PARP2) - catalytic domain in complex with olaparib | x-ray diffraction | A, B | — | — |
| 4TVJ | Human ARTD2 (PARP2) - catalytic domain in complex with olaparib | x-ray diffraction | A, B | — | — |
| 4ZZX | Structure of PARP2 catalytic domain bound to an isoindolinone inhibitor | x-ray diffraction | A, B | — | — |
| 4ZZY | Structure of human PARP2 catalytic domain bound to an isoindoli inhibitor | x-ray diffraction | A | — | — |
| 4ZZY | Structure of human PARP2 catalytic domain bound to an isoindolinone inhibitor | x-ray diffraction | A | — | — |
| 5D5K | Crystal structure nls from human parp-2 complexed with importin alpha delta ibb | x-ray diffraction | B | — | — |
| 5DSY | Crystal structure of constitutively active PARP-2 | x-ray diffraction | A, B, C, D | UHB | — |
| 5DSY | Crystal structure of constitutively active parp-2 | x-ray diffraction | A, B, C, D | — | — |
| 6F1K | Structure of ARTD2/PARP2 wgr domain bound to double strand DNA without 5'PHOSPHATE | x-ray diffraction | A | — | — |
| 6F5B | Structure of ARTD2/PARP2 WGR domain bound to double stranded DNA with 5'phosphate | x-ray diffraction | A, B | — | — |
| 6F5B | Structure of ARTD2/PARP2 wgr domain bound to double stranded DNA with 5'PHOSPHATE | x-ray diffraction | A, B | — | — |
| 6F5F | Structure of ARTD2/PARP2 wgr domain bound to double strand DNA with 5 nucleotide overhang and… | x-ray diffraction | A, B, C, D | — | — |
| 6TX3 | HPF1 bound to catalytic fragment of PARP2 | x-ray diffraction | B | UHB | — |
| 6USJ | Structure of two nucleosomes bridged by human PARP2 | electron microscopy | U, V | — | — |
| 6X0L | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | P, R | — | — |
| 6X0M | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | P, p | — | — |
| 6X0N | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | P, R | — | 5 (best 0.84) |
| 6X0N | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | P, R | — | — |
| 7AEO | Human ARTD2 in complex with DNA oligonucleotides | x-ray diffraction | A | SO4 | — |
| Q9UGN5 | AlphaFold monomer V2.0 prediction for poly [ADP-ribose] polymerase 2 (Q9UGN5) | — | — | — |
Ligands
Elsewhere
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