UniProt Q9UDR5
Alpha-aminoadipic semialdehyde synthase, mitochondrial (Q9UDR5)
Alpha-aminoadipic semialdehyde synthase, mitochondrial (UniProt Q9UDR5), EC 1.5.1.8, 1.5.1.9: 14 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 62 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9UDR5
- Protein
- Alpha-aminoadipic semialdehyde synthase, mitochondrial
- EC
- 1.5.1.8, 1.5.1.9
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 62 · 7 records with a druggable one
Structures
15 records of Q9UDR5 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L76 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A | — | 2 (best 0.73) |
| 5L76 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A | — | — |
| 5L78 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A, B | NAD | 8 (best 0.74) |
| 5L78 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A, B | NAD | — |
| 5O1N | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A | 9H8 | — |
| 5O1N | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A | 9H8 | — |
| 5O1O | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A, B | PRO | 5 (best 0.73) |
| 5O1O | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain… | x-ray diffraction | A, B | — | — |
| 5O1P | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase. | x-ray diffraction | A | — | 2 (best 0.73) |
| 5O1P | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase. | x-ray diffraction | A | — | — |
| 8DDA | Crystal structure of human aminoadipate semialdehyde synthase (AASS), lysine ketoglutarate… | x-ray diffraction | A, B, C, D | SO4 | 19 (best 0.81) |
| 8E8T | Structure of the short LOR domain of human AASS | x-ray diffraction | A, B | — | 6 (best 0.66) |
| 8E8U | Structure of the LOR domain of human AASS | x-ray diffraction | A, B, C, D | MG | 20 (best 0.82) |
| 8E8V | Structure of the short LOR domain of human AASS bound to N-ethylsuccinimide | x-ray diffraction | A, B, C, D | NEN | — |
| Q9UDR5 | AlphaFold monomer V2.0 prediction for alpha-aminoadipic semialdehyde synthase, mitochondrial… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5L78 chain A against the predicted model Q9UDR5: TM-score 0.99, RMSD 0.69 Å
- 5L78 chain A against the predicted model Q9UDR5: TM-score 0.99, RMSD 0.69 Å
- 5L76 chain A against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.18 Å
- 5L76 chain A against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.18 Å
- 5O1N chain A against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.29 Å
- 5O1N chain A against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.29 Å
- 8E8V chain C against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.27 Å
- 8E8V chain B against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.33 Å
- 8E8T chain A against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.28 Å
- 8E8V chain D against the predicted model Q9UDR5: TM-score 0.97, RMSD 1.31 Å
Elsewhere
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