MolNFT v1 · #128807 · protein
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.
5O1P · Alpha-aminoadipic semialdehyde synthase, mitochondrial: “Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.”. X-ray diffraction, 2 pockets (best druggability 0.73). MolNFT v1 #128807 on…
- PDB
- 5O1P
- Type
- protein
- Length
- 442 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-aminoadipic semialdehyde synthase, mitochondrial
- EC
- 1.5.1.8, 1.5.1.9
- UniProt
- Q9UDR5
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-aminoadipic semialdehyde synthase, mitochondrial (EC 1.5.1.8, 1.5.1.9) | protein | 442 | 38% helix, 24% strand | Q9UDR5 |
Ligands and binding sites
- DMS · Dimethyl sulfoxide · additive · 3 copies · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 763 | 0.73 | 0.78 | 75 | DMS |
| 2 | 112 | 0.41 | 0.76 | 20 | empty |
Compared structures
- 5O1P · Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase. · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UDR5 · AlphaFold monomer V2.0 prediction for alpha-aminoadipic semialdehyde synthase… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UDR5
- Elsewhere: RCSB PDB 5O1P · PDBe 5O1P · UniProt Q9UDR5
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