UniProt Q9TDR1
NADH-ubiquinone oxidoreductase chain 5 (Q9TDR1)
NADH-ubiquinone oxidoreductase chain 5 (UniProt Q9TDR1), EC 1.6.5.3, 7.1.1.2: 20 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 105 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9TDR1
- Protein
- NADH-ubiquinone oxidoreductase chain 5
- EC
- 1.6.5.3, 7.1.1.2
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 105 · 21 records with a druggable one
Structures
21 records of Q9TDR1 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5GPN | Architecture of mammalian respirasome | electron microscopy | j | — | 3 (best 0.84) |
| 5GUP | Cryo-EM structure of mammalian respiratory supercomplex I1III2IV1 | electron microscopy | l | CDL, PLX, ZMP, PEE | 3 (best 0.87) |
| 8UD1 | High resolution in-situ structure of complex I in respiratory supercomplex (composite) | electron microscopy | 1L | 3PE, CDL, PC1, MYR, EHZ | 6 (best 0.86) |
| 8UEO | In-situ complex I (Active-Apo) | electron microscopy | 1L | 3PE, CDL, PC1, MYR | 6 (best 0.86) |
| 8UEP | In-situ complex I, Active-Q10 (State-alpha) | electron microscopy | 1L | 3PE, PC1, MYR | 7 (best 0.84) |
| 8UEQ | In-situ complex I with Q10 (State-beta) | electron microscopy | 1L | MYR | 6 (best 0.85) |
| 8UER | In-situ complex I with Q10 (State-gamma) | electron microscopy | 1L | MYR, PC1, 3PE | 6 (best 0.88) |
| 8UES | In-situ complex I, Deactive class01 | electron microscopy | 1L | 3PE, PC1, MYR | 6 (best 0.84) |
| 8UET | In-situ complex I, Deactive class02 | electron microscopy | 1L | MYR, 3PE, PC1, EHZ | 5 (best 0.86) |
| 8UEU | In-situ complex I, Deactive class03 | electron microscopy | 1L | 3PE, PC1, MYR, EHZ | 6 (best 0.85) |
| 8UEV | In-situ complex I, Deactive class04 | electron microscopy | 1L | MYR, 3PE, PC1 | 7 (best 0.86) |
| 8UEW | In-situ complex I, Deactive class05 | electron microscopy | 1L | 3PE, PC1, MYR, EHZ | 5 (best 0.86) |
| 8UEX | In-situ complex I, Deactive class06 | electron microscopy | 1L | 3PE, PC1, MYR, EHZ | 6 (best 0.87) |
| 8UEY | In-situ complex I, Deactive class07 | electron microscopy | 1L | 3PE, PC1, MYR | 6 (best 0.87) |
| 8UEZ | In-situ complex I, Active-Q10 (State-delta) | electron microscopy | 1L | MYR, PC1 | 8 (best 0.84) |
| 8UGH | In-situ structure of typeA supercomplex with lipids in respiratory chain (composite) | electron microscopy | 1L | 3PE, CDL, PC1, MYR, EHZ, PGV | 3 (best 0.85) |
| 8UGI | High resolution in-situ structure of typeA supercomplex in respiratory chain (I1III2IV1,composite) | electron microscopy | 1L | 3PE, CDL, PC1, MYR, EHZ, PGV | 4 (best 0.85) |
| 8UGJ | In-situ structure of typeB supercomplex in respiratory chain (composite) | electron microscopy | 1L | 3PE, CDL, PC1, CHD, MYR, EHZ | 3 (best 0.86) |
| 8UGN | In-situ structure of typeO supercomplex in respiratory chain (composite) | electron microscopy | 1L, 5L | 3PE, CDL, PC1, EHZ, MYR, PGV | 1 (best 0.85) |
| 8UGR | In-situ structure of typeX supercomplex in respiratory chain (composite) | electron microscopy | 1L, 5L | 3PE, CDL, PC1, MYR, PGV | 2 (best 0.87) |
| Q9TDR1 | AlphaFold monomer V2.0 prediction for NADH-ubiquinone oxidoreductase chain 5 (Q9TDR1) | predicted | A | — | 6 (best 0.55) |
Ligands
- MYR · Myristic acid · in 18 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 17 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 16 records
- EHZ · ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate · in 9 records
- CDL · Cardiolipin · in 8 records
- PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · in 5 records
- CHD · Cholic acid · in 1 record
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · in 1 record
- ZMP · S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate · in 1 record
Experiment against prediction
- 8UD1 chain 1L against the predicted model Q9TDR1: TM-score 0.98, RMSD 1.44 Å
- 8UGI chain 1L against the predicted model Q9TDR1: TM-score 0.98, RMSD 1.45 Å
- 5GPN chain j against the predicted model Q9TDR1: TM-score 0.98, RMSD 1.46 Å
- 8UGJ chain 1L against the predicted model Q9TDR1: TM-score 0.98, RMSD 1.47 Å
- 8UGN chain 1L against the predicted model Q9TDR1: TM-score 0.98, RMSD 1.48 Å
- 8UGH chain 1L against the predicted model Q9TDR1: TM-score 0.97, RMSD 1.48 Å
- 8UGR chain 1L against the predicted model Q9TDR1: TM-score 0.97, RMSD 1.50 Å
- 8UEW chain 1L against the predicted model Q9TDR1: TM-score 0.97, RMSD 1.57 Å
- 8UEX chain 1L against the predicted model Q9TDR1: TM-score 0.97, RMSD 1.56 Å
- 8UEY chain 1L against the predicted model Q9TDR1: TM-score 0.97, RMSD 1.57 Å
Elsewhere
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