UniProt Q9R381
aminoglycoside 6'-N-acetyltransferase (Q9R381)
aminoglycoside 6'-N-acetyltransferase (UniProt Q9R381), EC 2.3.1.82: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9R381
- Protein
- aminoglycoside 6'-N-acetyltransferase
- EC
- 2.3.1.82
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 6 · 3 records with a druggable one
Structures
9 records of Q9R381 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S3Z | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and Ribostamycin | x-ray diffraction | A, B | NI, SO4, COA, RIO | 2 (best 0.70) |
| 1S3Z | Aminoglycoside N-acetyltransferase AAC(6')-iy in complex with CoA and ribostamycin | x-ray diffraction | A, B | — | — |
| 1S5K | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and N-terminal His(6)-tag… | x-ray diffraction | A, B | SO4, COA | 2 (best 0.66) |
| 1S5K | Aminoglycoside N-acetyltransferase AAC(6')-iy in complex with CoA and N-terminal HIS(6)-tag… | x-ray diffraction | A, B | — | — |
| 1S60 | Aminoglycoside N-Acetyltransferase AAC(6')-Iy in Complex with CoA and N-terminal His(6)-tag… | x-ray diffraction | A | SO4, COA | 2 (best 0.63) |
| 1S60 | Aminoglycoside N-acetyltransferase AAC(6')-iy in complex with CoA and N-terminal HIS(6)-tag… | x-ray diffraction | A | — | — |
| 2VBQ | Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. | x-ray diffraction | A, B | — | — |
| 2VBQ | Structure of AAC(6')-iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine. | x-ray diffraction | A, B | — | — |
| Q9R381 | AlphaFold monomer V2.0 prediction for aminoglycoside N(6')-acetyltransferase type 1 (Q9R381) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1S60 chain A against the predicted model Q9R381: TM-score 0.93, RMSD 0.85 Å
- 1S60 chain A against the predicted model Q9R381: TM-score 0.93, RMSD 0.85 Å
- 1S3Z chain A against the predicted model Q9R381: TM-score 0.95, RMSD 0.91 Å
- 1S3Z chain A against the predicted model Q9R381: TM-score 0.95, RMSD 0.91 Å
- 2VBQ chain A against the predicted model Q9R381: TM-score 0.95, RMSD 0.93 Å
- 2VBQ chain A against the predicted model Q9R381: TM-score 0.95, RMSD 0.93 Å
- 1S5K chain A against the predicted model Q9R381: TM-score 0.91, RMSD 0.95 Å
- 1S5K chain A against the predicted model Q9R381: TM-score 0.91, RMSD 0.95 Å
- 1S3Z chain B against the predicted model Q9R381: TM-score 0.96, RMSD 1.04 Å
- 1S3Z chain B against the predicted model Q9R381: TM-score 0.96, RMSD 1.04 Å
Elsewhere
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