UniProt Q9R1A9
Three prime repair exonuclease 2 (Q9R1A9)
Three prime repair exonuclease 2 (UniProt Q9R1A9), EC 3.1.11.2: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9R1A9
- Protein
- Three prime repair exonuclease 2
- EC
- 3.1.11.2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 37 · 5 records with a druggable one
Structures
9 records of Q9R1A9 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6A45 | Structure of mouse TREX2 | x-ray diffraction | A, B | PO4 | 3 (best 0.63) |
| 6A45 | Structure of mouse TREX2 | x-ray diffraction | A, B | PO4 | — |
| 6A46 | Structure of TREX2 in complex with a nucleotide (dCMP) | x-ray diffraction | A, B | MG, DCM, CA | 5 (best 0.57) |
| 6A46 | Structure of TREX2 in complex with a nucleotide (dcmp) | x-ray diffraction | A, B | MG, DCM, CA | — |
| 6A47 | Structure of TREX2 in complex with a Y structured dsDNA | x-ray diffraction | A, B | MG, NA | 7 (best 0.55) |
| 6A47 | Structure of TREX2 in complex with a Y structured dsdna | x-ray diffraction | A, B | MG, NA | — |
| 6A4B | Structure of TREX2 in complex with a duplex DNA with 2 nucleotide 3'-overhang | x-ray diffraction | A, B, C, D, E, F | MG | 20 (best 0.66) |
| 6A4B | Structure of TREX2 in complex with a duplex DNA with 2 nucleotide 3'- overhang | x-ray diffraction | A, B, C, D, E, F | MG | — |
| Q9R1A9 | AlphaFold monomer V2.0 prediction for three prime repair exonuclease 2 (Q9R1A9) | predicted | A | — | 2 (best 0.51) |
Ligands
Experiment against prediction
- 6A46 chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.45 Å
- 6A46 chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.45 Å
- 6A4B chain A against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.51 Å
- 6A4B chain A against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.51 Å
- 6A4B chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.52 Å
- 6A4B chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.52 Å
- 6A4B chain E against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.58 Å
- 6A4B chain E against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.58 Å
- 6A47 chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.62 Å
- 6A47 chain B against the predicted model Q9R1A9: TM-score 0.99, RMSD 0.62 Å
Elsewhere
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