UniProt Q9P2J5
Leucine--tRNA ligase, cytoplasmic (Q9P2J5)
Leucine--tRNA ligase, cytoplasmic (UniProt Q9P2J5), EC 6.1.1.4: 13 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9P2J5
- Protein
- Leucine--tRNA ligase, cytoplasmic
- EC
- 6.1.1.4
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 41 · 3 records with a druggable one
Structures
14 records of Q9P2J5 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WFD | Structure of the human cytosolic leucyl-tRNA synthetase editing domain | x-ray diffraction | A, B | — | — |
| 2WFD | Structure of the human cytosolic leucyl-tRNA synthetase editing domain | x-ray diffraction | A, B | — | — |
| 6KID | Crystal structure of human leucyl-tRNA synthetase, ATP-bound form | x-ray diffraction | A | ATP, PO4 | — |
| 6KIE | Crystal structure of human leucyl-tRNA synthetase, Leu-AMS-bound form | x-ray diffraction | A | PO4, LSS, LEU | 10 (best 0.77) |
| 6KIE | Crystal structure of human leucyl-tRNA synthetase, leu-ams-bound form | x-ray diffraction | A | PO4, LSS | — |
| 6KQY | Crystal structure of human leucyl-tRNA synthetase, Leucine-bound form | x-ray diffraction | A | PO4 | — |
| 6KQY | Crystal structure of human leucyl-tRNA synthetase, leucine-bound form | x-ray diffraction | A | PO4 | — |
| 6KR7 | Crystal structure of methylated human leucyl-tRNA synthetase, Leu-AMS-bound form | x-ray diffraction | A | LSS, PO4 | — |
| 6KR7 | Crystal structure of methylated human leucyl-tRNA synthetase, leu-ams- bound form | x-ray diffraction | A | LSS, PO4 | — |
| 6LPF | The crystal structure of human cytoplasmic LRS | x-ray diffraction | A, B | LSS | — |
| 6LPF | The crystal structure of human cytoplasmic lrs | x-ray diffraction | A, B | LSS | — |
| 6LR6 | The crystal structure of human cytoplasmic LRS | x-ray diffraction | A, B | LSS, A2H | 19 (best 0.75) |
| 6LR6 | The crystal structure of human cytoplasmic lrs | x-ray diffraction | A, B | LSS, A2H | — |
| Q9P2J5 | AlphaFold monomer V2.0 prediction for leucine--tRNA ligase, cytoplasmic (Q9P2J5) | predicted | A | — | 12 (best 0.82) |
Ligands
Experiment against prediction
- 2WFD chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 0.65 Å
- 2WFD chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 0.65 Å
- 6LPF chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 1.26 Å
- 6LPF chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 1.26 Å
- 6LR6 chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 1.28 Å
- 6LR6 chain A against the predicted model Q9P2J5: TM-score 0.99, RMSD 1.28 Å
- 6KR7 chain A against the predicted model Q9P2J5: TM-score 0.98, RMSD 1.48 Å
- 6KR7 chain A against the predicted model Q9P2J5: TM-score 0.98, RMSD 1.48 Å
- 6KID chain A against the predicted model Q9P2J5: TM-score 0.98, RMSD 1.64 Å
- 6KIE chain A against the predicted model Q9P2J5: TM-score 0.97, RMSD 1.96 Å
Elsewhere
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