UniProt Q9NZK7
Group IIE secretory phospholipase A2 (Q9NZK7)
Group IIE secretory phospholipase A2 (UniProt Q9NZK7), EC 3.1.1.4: 18 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NZK7
- Protein
- Group IIE secretory phospholipase A2
- EC
- 3.1.1.4
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 8 · 6 records with a druggable one
Structures
19 records of Q9NZK7 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WZM | Crystal structure of human secreted phospholipase A2 group IIE | x-ray diffraction | A | CL, CA | 1 (best 0.47) |
| 5WZM | Crystal structure of human secreted phospholipase A2 group iie | x-ray diffraction | A | CL, CA | — |
| 5WZO | Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium | x-ray diffraction | A | CL, CA | 1 (best 0.51) |
| 5WZO | Crystal structure of human secreted phospholipase A2 group iie, crystallized with calcium | x-ray diffraction | A | CL, CA | — |
| 5WZS | Crystal structure of human secreted phospholipase A2 group IIE with Compound 8 | x-ray diffraction | A | 7W9, CA, CL | 1 (best 0.57) |
| 5WZS | Crystal structure of human secreted phospholipase A2 group iie with compound 8 | x-ray diffraction | A | 7W9, CA, CL | — |
| 5WZT | Crystal structure of human secreted phospholipase A2 group IIE with Compound 14 | x-ray diffraction | A | CA, 7W6 | 1 (best 0.58) |
| 5WZT | Crystal structure of human secreted phospholipase A2 group iie with compound 14 | x-ray diffraction | A | CA, 7W6 | — |
| 5WZU | Crystal structure of human secreted phospholipase A2 group IIE with Compound 24 | x-ray diffraction | A | CA, 7W3, CL | — |
| 5WZU | Crystal structure of human secreted phospholipase A2 group iie with compound 24 | x-ray diffraction | A | CA, 7W3, CL | — |
| 5WZV | Crystal structure of human secreted phospholipase A2 group IIE with Me-indoxam | x-ray diffraction | A | CA, 7W0, CL | 1 (best 0.52) |
| 5WZV | Crystal structure of human secreted phospholipase A2 group iie with me-indoxam | x-ray diffraction | A | CA, 7W0, CL | — |
| 5WZW | Crystal structure of human secreted phospholipase A2 group IIE with LY311727 | x-ray diffraction | A | CL, CA, U8D | 1 (best 0.55) |
| 5WZW | Crystal structure of human secreted phospholipase A2 group iie with LY311727 | x-ray diffraction | A | CL, CA, U8D | — |
| 5Y5E | Crystal structure of phospholipase A2 with inhibitor | x-ray diffraction | A | 7W3, CL, CA, NA | — |
| 5Y5E | Crystal structure of phospholipase A2 with inhibitor | x-ray diffraction | A | 7W3, CL, CA, NA | — |
| 6KQU | Crystal structure of phospholipase A2 | x-ray diffraction | A | CL, NA, CA | 1 (best 0.48) |
| 6KQU | Crystal structure of phospholipase A2 | x-ray diffraction | A | CL, NA, CA | — |
| Q9NZK7 | AlphaFold monomer V2.0 prediction for group iie secretory phospholipase A2 (Q9NZK7) | predicted | A | — | 1 (best 0.56) |
Ligands
- CA · Calcium ion · in 18 records
- CL · Chloride ion · in 16 records
- 7W3 · 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl) phenyl]methyl]indol-4-yl]oxyethanoic acid · in 4 records
- NA · Sodium ion · in 4 records
- 7W0 · 2-[2-methyl-3-oxamoyl-1-[(2-phenylphenyl)methyl]indol-4-yl]oxyethanoic acid · in 2 records
- 7W6 · 2-[1-[(3-bromophenyl)methyl]-2-methyl-3-oxamoyl-indol-4-yl]oxyethanoic acid · in 2 records
- 7W9 · 2-[2-methyl-1-(naphthalen-1-ylmethyl)-3-oxamoyl-indol-4-yl]oxyethanoic acid · in 2 records
- U8D · (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid · in 2 records
Experiment against prediction
- 5WZM chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.79 Å
- 5WZM chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.79 Å
- 5WZT chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.83 Å
- 5WZT chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.83 Å
- 5WZU chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.83 Å
- 5WZU chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.83 Å
- 5WZW chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.82 Å
- 5WZW chain A against the predicted model Q9NZK7: TM-score 0.97, RMSD 0.82 Å
- 5WZS chain A against the predicted model Q9NZK7: TM-score 0.96, RMSD 0.85 Å
- 5WZS chain A against the predicted model Q9NZK7: TM-score 0.96, RMSD 0.85 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.