UniProt Q9NZJ5
Eukaryotic translation initiation factor 2-alpha kinase 3 (Q9NZJ5)
Eukaryotic translation initiation factor 2-alpha kinase 3 (UniProt Q9NZJ5), EC 2.7.11.1: 26 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 41 pockets. Binding sites, druggability and experiment…
- UniProt
- Q9NZJ5
- Protein
- Eukaryotic translation initiation factor 2-alpha kinase 3
- EC
- 2.7.11.1
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 41 · 15 records with a druggable one
Structures
27 records of Q9NZJ5 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4G31 | Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution | x-ray diffraction | A | 0WH | 1 (best 0.73) |
| 4G31 | Crystal structure of GSK6414 bound to perk (R587-R1092, delete A660- T867) at 2.28 a resolution | x-ray diffraction | A | — | — |
| 4G34 | Crystal Structure of GSK6924 Bound to PERK (R587-R1092, delete A660-T867) at 2.70 A Resolution | x-ray diffraction | A | 924 | 1 (best 0.72) |
| 4G34 | Crystal structure of GSK6924 bound to perk (R587-R1092, delete A660- T867) at 2.70 a resolution | x-ray diffraction | A | — | — |
| 4M7I | Crystal Structure of GSK6157 Bound to PERK (R587-R1092, delete A660-T867) at 2.34A Resolution | x-ray diffraction | A | 27D | 1 (best 0.74) |
| 4M7I | Crystal structure of GSK6157 bound to perk (R587-R1092, delete A660- T867) at 2.34A resolution | x-ray diffraction | A | — | — |
| 4X7H | Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3… | x-ray diffraction | A | 3Z2, SO4 | 2 (best 0.75) |
| 4X7H | Co-crystal structure of perk bound to N-{5-[(6,7-dimethoxyquinolin-4… | x-ray diffraction | A | — | — |
| 4X7J | Co-crystal Structure of PERK with 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(met… | x-ray diffraction | A | 3Z1 | 2 (best 0.77) |
| 4X7J | Co-crystal structure of perk with 2-amino-N-[4-methoxy-3… | x-ray diffraction | A | — | — |
| 4X7K | Co-crystal Structure of PERK bound to 4-{2-amino-3-[5-fluoro-2-(methylamino)quinazolin-6-yl]-4-methy… | x-ray diffraction | A | 3Z3 | 2 (best 0.76) |
| 4X7K | Co-crystal structure of perk bound to 4-{2-amino-3-[5-fluoro-2… | x-ray diffraction | A | — | — |
| 4X7L | Co-crystal Structure of PERK bound to 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]b… | x-ray diffraction | A | 3Z4 | 2 (best 0.76) |
| 4X7L | Co-crystal structure of perk bound to 4-{2-amino-4-methyl-3-[2… | x-ray diffraction | A | — | — |
| 4X7N | Co-crystal Structure of PERK bound to 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl… | x-ray diffraction | A | 3Z5 | 2 (best 0.78) |
| 4X7N | Co-crystal structure of perk bound to 4-[2-amino-4-methyl-3-(2… | x-ray diffraction | A | — | — |
| 4X7O | Co-crystal Structure of PERK bound to 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2… | x-ray diffraction | A | 3Z6 | 1 (best 0.73) |
| 4X7O | Co-crystal structure of perk bound to 1-[5-(4-amino-2,7-dimethyl-7H… | x-ray diffraction | A | — | — |
| 4YZS | Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling | x-ray diffraction | A, B | W | 7 (best 0.51) |
| 4YZS | Crystal structures reveal transient perk luminal domain tetramerization in er stress signaling | x-ray diffraction | A, B | — | — |
| 5SV7 | The Crystal structure of a chaperone | x-ray diffraction | A, B, C, D | — | 14 (best 0.68) |
| 5SV7 | The crystal structure of a chaperone | x-ray diffraction | A, B, C, D | — | — |
| 7MF0 | Co-crystal structure of PERK with inhibitor (R)-2-amino-N-cyclopropyl-5-(4-(2-(3,5-difluorophenyl)-2… | x-ray diffraction | AAA | Z6P | 1 (best 0.72) |
| 8EQ9 | Co-crystal structure of PERK with compound 11 | x-ray diffraction | AAA | WPB | 2 (best 0.73) |
| 8EQD | Co-crystal structure of PERK with compound 24 | x-ray diffraction | AAA | WPX | 1 (best 0.76) |
| 8EQE | Co-crystal structure of PERK with compound 26 | x-ray diffraction | AAA | WQ2 | 2 (best 0.74) |
| Q9NZJ5 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2-alpha kinase 3… | predicted | A | — | — |
Ligands
- 0WH · 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone · in 1 record
- 27D · 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-1H-indol-1-yl]-2-(6-methylpyridin-2-yl)ethanone · in 1 record
- 3Z1 · 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide · in 1 record
- 3Z2 · N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide · in 1 record
- 3Z3 · 4-{2-amino-3-[5-fluoro-2-(methylamino)quinazolin-6-yl]-4-methylbenzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one · in 1 record
- 3Z4 · 4-{2-amino-4-methyl-3-[2-(methylamino)-1,3-benzothiazol-6-yl]benzoyl}-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one · in 1 record
- 3Z5 · 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one · in 1 record
- 3Z6 · 1-[5-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone · in 1 record
- 924 · 1-[5-(4-aminothieno[3,2-c]pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]-2-phenylethanone · in 1 record
- SO4 · Sulfate ion · in 1 record
- W · Tungsten ion · in 1 record
- WPB · (2R)-N-[(4M)-4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide · in 1 record
- WPX · (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamide · in 1 record
- WQ2 · (2R)-N-[(4M)-4-(4-amino-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetamide · in 1 record
- Z6P · 2-amino-N-cyclopropyl-5-(4-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}-2-methylphenyl)pyridine-3-carboxamide · in 1 record
Experiment against prediction
- 4X7O chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.02 Å
- 4X7O chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.02 Å
- 4M7I chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.14 Å
- 4M7I chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.14 Å
- 4X7H chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.30 Å
- 4X7H chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.30 Å
- 4G34 chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.15 Å
- 4G34 chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.15 Å
- 4G31 chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.19 Å
- 4G31 chain A against the predicted model Q9NZJ5: TM-score 0.97, RMSD 1.19 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.