MolNFT v1 · #134135 · protein
The crystal structure of a chaperone
5SV7 · Eukaryotic translation initiation factor 2-alpha kinase 3: “The crystal structure of a chaperone”. X-ray diffraction, 14 pockets (best druggability 0.68). MolNFT v1 #134135 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5SV7
- Type
- protein
- Length
- 842 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 2-alpha kinase 3
- EC
- 2.7.11.1
- UniProt
- Q9NZJ5
- Pockets
- 14 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) | protein | 203 | 2% helix, 47% strand | Q9NZJ5 |
| B | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) | protein | 224 | 8% helix, 41% strand | Q9NZJ5 |
| C | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) | protein | 206 | 4% helix, 53% strand | Q9NZJ5 |
| D | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) | protein | 209 | 9% helix, 42% strand | Q9NZJ5 |
Pockets
14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.68 | 0.82 | 31 | empty |
| 2 | 519 | 0.67 | 0.78 | 52 | empty |
| 3 | 384 | 0.60 | 0.77 | 52 | empty |
| 4 | 321 | 0.56 | 0.76 | 32 | empty |
| 5 | 92 | 0.54 | 0.84 | 27 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1320 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1283 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 1083 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 1051 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZJ5
- Elsewhere: RCSB PDB 5SV7 · PDBe 5SV7 · UniProt Q9NZJ5
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