UniProt Q9NYZ4
Sialic acid-binding Ig-like lectin 8 (Q9NYZ4)
Sialic acid-binding Ig-like lectin 8 (UniProt Q9NYZ4): 7 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NYZ4
- Protein
- Sialic acid-binding Ig-like lectin 8
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 11 · 3 records with a druggable one
Structures
8 records of Q9NYZ4 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2N7A | Solution structure of the human Siglec-8 lectin domain | solution nmr | A | — | — |
| 2N7A | Solution structure of the human siglec-8 lectin domain | solution nmr | A | — | — |
| 2N7B | Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx | solution nmr | A | NAG, G6S, SIA, 0D8 | — |
| 2N7B | Solution structure of the human siglec-8 lectin domain in complex with 6'SULFO sialyl lewisx | solution nmr | A | NAG, G6S, SIA, 0D8 | — |
| 7QU6 | Crystal structure of the N-terminal domain of Siglec-8 | x-ray diffraction | B, A, C, D, E, F | — | 9 (best 0.71) |
| 7QUH | Siglec-8 in complex with therapeutic Fab AK002. | x-ray diffraction | A | — | 1 (best 0.59) |
| 7QUI | Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside… | x-ray diffraction | B, A | F9I | 1 (best 0.72) |
| Q9NYZ4 | AlphaFold monomer V2.0 prediction for sialic acid-binding ig-like lectin 8 (Q9NYZ4) | predicted | A | — | — |
Ligands
- 0D8 · 3-aminopropan-1-ol · in 2 records
- G6S · 6-O-sulfo-beta-D-galactopyranose · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- SIA · N-acetyl-alpha-neuraminic acid · in 2 records
- F9I · (2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid · in 1 record
Experiment against prediction
- 7QU6 chain B against the predicted model Q9NYZ4: TM-score 0.97, RMSD 0.69 Å
- 7QU6 chain D against the predicted model Q9NYZ4: TM-score 0.96, RMSD 1.14 Å
- 7QUI chain A against the predicted model Q9NYZ4: TM-score 0.95, RMSD 1.14 Å
- 7QUI chain B against the predicted model Q9NYZ4: TM-score 0.95, RMSD 1.16 Å
- 7QUH chain A against the predicted model Q9NYZ4: TM-score 0.95, RMSD 1.43 Å
- 7QU6 chain F against the predicted model Q9NYZ4: TM-score 0.92, RMSD 1.65 Å
- 7QU6 chain C against the predicted model Q9NYZ4: TM-score 0.92, RMSD 1.67 Å
- 2N7A chain A against the predicted model Q9NYZ4: TM-score 0.91, RMSD 1.77 Å
- 2N7A chain A against the predicted model Q9NYZ4: TM-score 0.91, RMSD 1.77 Å
- 2N7B chain A against the predicted model Q9NYZ4: TM-score 0.90, RMSD 1.76 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.