UniProt Q9NWY4
Histone PARylation factor 1 (Q9NWY4)
Histone PARylation factor 1 (UniProt Q9NWY4): 14 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NWY4
- Protein
- Histone PARylation factor 1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 20 · 4 records with a druggable one
Structures
15 records of Q9NWY4 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6M3G | Crystal structure of human HPF1 | x-ray diffraction | A | — | 1 (best 0.30) |
| 6M3G | Crystal structure of human HPF1 | x-ray diffraction | A | — | — |
| 6M3I | Crystal structure of HPF1/PARP1 complex | x-ray diffraction | A | — | — |
| 6M3I | Crystal structure of HPF1/PARP1 complex | x-ray diffraction | A | — | — |
| 6TX2 | Human HPF1 | x-ray diffraction | A | NA | 1 (best 0.34) |
| 6TX2 | HUMAN HPF1 | x-ray diffraction | A | NA | — |
| 6TX3 | HPF1 bound to catalytic fragment of PARP2 | x-ray diffraction | A | — | 3 (best 0.70) |
| 6TX3 | HPF1 bound to catalytic fragment of PARP2 | x-ray diffraction | A | — | — |
| 6X0L | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O | — | 4 (best 0.87) |
| 6X0L | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O | — | — |
| 6X0M | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O, o | — | 9 (best 0.86) |
| 6X0M | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O, o | — | — |
| 6X0N | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O | — | 2 (best 0.84) |
| 6X0N | Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin | electron microscopy | O | — | — |
| Q9NWY4 | AlphaFold monomer V2.0 prediction for histone parylation factor 1 (Q9NWY4) | predicted | A | — | — |
Ligands
- NA · Sodium ion · in 2 records
Experiment against prediction
- 6TX2 chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.41 Å
- 6TX2 chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.41 Å
- 6M3G chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.40 Å
- 6M3G chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.40 Å
- 6TX3 chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.47 Å
- 6TX3 chain A against the predicted model Q9NWY4: TM-score 1.00, RMSD 0.47 Å
- 6X0L chain O against the predicted model Q9NWY4: TM-score 0.99, RMSD 0.64 Å
- 6X0L chain O against the predicted model Q9NWY4: TM-score 0.99, RMSD 0.64 Å
- 6X0N chain O against the predicted model Q9NWY4: TM-score 0.99, RMSD 0.64 Å
- 6X0N chain O against the predicted model Q9NWY4: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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