UniProt Q9NR48
Histone-lysine N-methyltransferase ASH1L (Q9NR48)
Histone-lysine N-methyltransferase ASH1L (UniProt Q9NR48), EC 2.1.1.-, 2.1.1.359: 23 experimental structures on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9NR48
- Protein
- Histone-lysine N-methyltransferase ASH1L
- EC
- 2.1.1.-, 2.1.1.359, 2.1.1.43
- Experimental structures
- 23
- Predicted models
- 0
- Ligands
- 4
- Pockets
- 17 · 3 records with a druggable one
Structures
23 records of Q9NR48 in the MolNFT archive: 23 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3MQM | Crystal Structure of the Bromodomain of human ASH1L | x-ray diffraction | A, B | — | — |
| 3MQM | Crystal structure of the bromodomain of human ASH1L | x-ray diffraction | A, B | — | — |
| 3OPE | Structural Basis of Auto-inhibitory mechanism of Histone methyltransferase | x-ray diffraction | A, B | — | — |
| 3OPE | Structural basis of auto-inhibitory mechanism of histone methyltransferase | x-ray diffraction | A, B | — | — |
| 4YNM | ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YNM | ASH1L wild-type set domain in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YNP | ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YNP | ASH1L set domain S2259M mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YPA | ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B, C, D | — | — |
| 4YPA | ASH1L set domain Q2265A mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B, C, D | — | — |
| 4YPE | ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YPE | ASH1L set domain H2193F mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YPU | ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 4YPU | ASH1L set domain K2264L mutant in complex with S-adenosyl methionine (SAM) | x-ray diffraction | A, B | — | — |
| 6AGO | Crystal structure of MRG15-ASH1L Histone methyltransferase complex | x-ray diffraction | A, B | SAM, ZN | 8 (best 0.83) |
| 6AGO | Crystal structure of MRG15-ASH1L histone methyltransferase complex | x-ray diffraction | A, B | ZN | — |
| 6INE | Crystal Structure of human ASH1L-MRG15 complex | x-ray diffraction | A | ZN | — |
| 6INE | Crystal structure of human ASH1L-MRG15 complex | x-ray diffraction | A | ZN | — |
| 6WZW | Ash1L SET domain in complex with AS-85 | x-ray diffraction | A | SAM, ZN, UG7 | 1 (best 0.66) |
| 6WZW | ASH1L set domain in complex with as-85 | x-ray diffraction | A | ZN, UG7 | — |
| 6X0P | Ash1L SET domain Q2265A mutant in complex with AS-5 | x-ray diffraction | A, B, C, D | UK7, ZN, SAM | 8 (best 0.78) |
| 6X0P | ASH1L set domain Q2265A mutant in complex with as-5 | x-ray diffraction | A, B, C, D | UK7, ZN | — |
| 7Y0I | Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide | solution nmr | A | ZN | — |
Ligands
- ZN · Zinc ion · in 9 records
- SAM · S-adenosylmethionine · in 3 records
- UG7 · N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl) sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide · in 2 records
- UK7 · 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide · in 2 records
Elsewhere
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