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Ligand · UK7

UK7 · 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide

UK7, 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide (C18 H19 N3 O S, 325.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
UK7
Formula
C18 H19 N3 O S
Class
ligand
Structures
2
PDB entries
1

Binding sites

UK7 in 2 structures; the first of them:

  • 6X0P · Ash1L SET domain Q2265A mutant in complex with AS-5 · UK7 A2301 · binds HIS2193, TYR2194, CYS2195, TYR2255, ASN2256, SER2259, PHE2260, ASN2261 and 9 more
  • 6X0P · ASH1L set domain Q2265A mutant in complex with as-5 · UK7 A2301 · binds HIS2193, TYR2194, CYS2195, TYR2255, ASN2256, SER2259, PHE2260, ASN2261 and 8 more

Residues it binds most

ASN 8, GLY 8, ILE 8, TYR 8, CYS 8, GLN 8, HIS 8, LYS 8, PHE 8, SER 8 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • SAM · S-adenosylmethionine

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