UniProt Q9M548
DNA (cytosine-5)-methyltransferase DRM2 (Q9M548)
DNA (cytosine-5)-methyltransferase DRM2 (UniProt Q9M548), EC 2.1.1.37: 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9M548
- Protein
- DNA (cytosine-5)-methyltransferase DRM2
- EC
- 2.1.1.37
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 41 · 4 records with a druggable one
Structures
11 records of Q9M548 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7L4C | Crystal structure of the DRM2-ctt DNA complex | x-ray diffraction | A | — | — |
| 7L4F | Crystal structure of the DRM2-cat DNA complex | x-ray diffraction | B, A | — | — |
| 7L4H | Crystal structure of the DRM2-CTG DNA complex | x-ray diffraction | A | SAH, IOD | 8 (best 0.66) |
| 7L4H | Crystal structure of the DRM2-ctg DNA complex | x-ray diffraction | A | IOD | — |
| 7L4K | Crystal structure of the DRM2-CCG DNA complex | x-ray diffraction | A | SAH | 8 (best 0.73) |
| 7L4K | Crystal structure of the DRM2-ccg DNA complex | x-ray diffraction | A | — | — |
| 7L4M | Crystal structure of the DRM2-CCT DNA complex | x-ray diffraction | B, A | SAH | 20 (best 0.76) |
| 7L4M | Crystal structure of the DRM2-cct DNA complex | x-ray diffraction | B, A | — | — |
| 7L4N | Crystal structure of the DRM2 (C397R)-CCG DNA complex | x-ray diffraction | A | SAH | 5 (best 0.71) |
| 7L4N | Crystal structure of the DRM2 (C397R)-ccg DNA complex | x-ray diffraction | A | — | — |
| Q9M548 | AlphaFold monomer V2.0 prediction for DNA (cytosine-5)-methyltransferase DRM2 (Q9M548) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7L4M chain B against the predicted model Q9M548: TM-score 0.97, RMSD 1.29 Å
- 7L4F chain B against the predicted model Q9M548: TM-score 0.97, RMSD 1.24 Å
- 7L4M chain B against the predicted model Q9M548: TM-score 0.97, RMSD 1.29 Å
- 7L4M chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.34 Å
- 7L4K chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.46 Å
- 7L4N chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.46 Å
- 7L4H chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.47 Å
- 7L4M chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.34 Å
- 7L4K chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.46 Å
- 7L4N chain A against the predicted model Q9M548: TM-score 0.97, RMSD 1.46 Å
Elsewhere
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