UniProt Q9LK40
DNA-directed RNA polymerases IV and V subunit 2 (Q9LK40)
DNA-directed RNA polymerases IV and V subunit 2 (UniProt Q9LK40), EC 2.7.7.6: 7 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 77 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9LK40
- Protein
- DNA-directed RNA polymerases IV and V subunit 2
- EC
- 2.7.7.6
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 77 · 6 records with a druggable one
Structures
8 records of Q9LK40 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EU0 | The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | electron microscopy | B | ZN | 12 (best 0.87) |
| 7EU0 | The cryo-EM structure of a. thaliana pol IV-RDR2 backtracked complex | electron microscopy | B | ZN | — |
| 7EU1 | The cryo-EM structure of a. thaliana pol IV-RDR2 holoenzyme | electron microscopy | B | ZN | — |
| 8HYJ | A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex | electron microscopy | B | — | 13 (best 0.84) |
| 8XMB | NTP-bound Pol IV transcription elongation complex | electron microscopy | B | MG, ZN, GTP | 12 (best 0.84) |
| 8XMD | Pre-translocated Pol IV transcription elongation complex | electron microscopy | B | ZN | 10 (best 0.87) |
| 8XME | Backtracked Pol IV transcription elongation complex | electron microscopy | B | ZN | 12 (best 0.86) |
| Q9LK40 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases IV and V subunit 2 (Q9LK40) | predicted | A | — | 18 (best 0.74) |
Ligands
Experiment against prediction
- 8XMD chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 1.95 Å
- 8XME chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 1.96 Å
- 8XMB chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 1.97 Å
- 8HYJ chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 2.04 Å
- 7EU0 chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 2.06 Å
- 7EU0 chain B against the predicted model Q9LK40: TM-score 0.97, RMSD 2.06 Å
- 7EU1 chain B against the predicted model Q9LK40: TM-score 0.96, RMSD 2.42 Å
Elsewhere
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