MolNFT v1 · #270278 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases IV and V subunit 2 (Q9LK40)
Q9LK40: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerases IV and V subunit 2 (Q9LK40)”. 18 pockets (best druggability 0.74). MolNFT v1 #270278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9LK40
- Type
- protein
- Length
- 1,172 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x40B9C9d5F084D34d026E9d5Dd10501AcdF6d6152
- Molecule
- DNA-directed RNA polymerases IV and V subunit 2
- UniProt
- Q9LK40
- Pockets
- 18 · best druggability 0.74
Structure
1 distinct chain · 29% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerases IV and V subunit 2 | protein | 1172 | 29% helix, 26% strand | Q9LK40 |
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 796 | 0.74 | 0.79 | 69 | empty |
| 2 | 238 | 0.64 | 0.82 | 36 | empty |
| 3 | 368 | 0.60 | 0.76 | 43 | empty |
| 4 | 347 | 0.59 | 0.77 | 40 | empty |
| 5 | 216 | 0.55 | 0.79 | 36 | empty |
Compared structures
- 8XMC · Post-translocated Pol IV transcription elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.90
- 8XMB · NTP-bound Pol IV transcription elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.88
- 8XMD · Pre-translocated Pol IV transcription elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.88
- 8XME · Backtracked Pol IV transcription elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.88
- 7EU1 · The cryo-EM structure of A. thaliana Pol IV-RDR2 holoenzyme · an experimental structure of the same protein · chain A against B, TM-score 0.88
- 7EU1 · The cryo-EM structure of a. thaliana pol IV-RDR2 holoenzyme · an experimental structure of the same protein · chain A against B, TM-score 0.88
- 8HYJ · A cryo-EM structure of KTF1-bound polymerase V transcription elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.87
- 7EU0 · The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex · an experimental structure of the same protein · chain A against B, TM-score 0.87
- 7EU0 · The cryo-EM structure of a. thaliana pol IV-RDR2 backtracked complex · an experimental structure of the same protein · chain A against B, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9LK40
- Elsewhere: UniProt Q9LK40 · AlphaFold DB Q9LK40
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