UniProt Q9KWU8
DNA-directed RNA polymerase subunit alpha (Q9KWU8)
DNA-directed RNA polymerase subunit alpha (UniProt Q9KWU8), EC 2.7.7.6: 26 experimental structures and 1 predicted model on GenesisL1, 147 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9KWU8
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 26
- Predicted models
- 1
- Pockets
- 147 · 26 records with a druggable one
Structures
27 records of Q9KWU8 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HQM | Crystal structure of thermus aquaticus core RNA polymerase-includes complete structure with… | x-ray diffraction | A, B | — | 7 (best 0.83) |
| 1HQM | Crystal structure of thermus aquaticus core RNA polymerase-includes complete structure with… | x-ray diffraction | A, B | — | 7 (best 0.83) |
| 1I6V | Thermus aquaticus core RNA polymerase-rifampicin complex | x-ray diffraction | A, B | — | 4 (best 0.85) |
| 1I6V | Thermus aquaticus core RNA polymerase-rifampicin complex | x-ray diffraction | A, B | — | 4 (best 0.85) |
| 1L9U | Thermus aquaticus RNA polymerase holoenzyme at 4 a resolution | x-ray diffraction | A, B, J, K | — | 6 (best 0.68) |
| 1L9U | Thermus aquaticus RNA polymerase holoenzyme at 4 a resolution | x-ray diffraction | A, B, J, K | — | 6 (best 0.68) |
| 1L9Z | Thermus aquaticus RNA Polymerase Holoenzyme/Fork-Junction Promoter DNA Complex at 6.5 A Resolution | x-ray diffraction | A, B | — | 5 (best 0.68) |
| 1L9Z | Thermus aquaticus RNA polymerase HOLOENZYME/FORK-junction promoter DNA complex at 6.5 a resolution | x-ray diffraction | A, B | — | 5 (best 0.68) |
| 1YNJ | Taq RNA polymerase-Sorangicin complex | x-ray diffraction | A, B | — | 8 (best 0.85) |
| 1YNJ | Taq RNA polymerase-sorangicin complex | x-ray diffraction | A, B | — | 8 (best 0.85) |
| 1YNN | Taq RNA polymerase-rifampicin complex | x-ray diffraction | A, B | — | 5 (best 0.86) |
| 1YNN | Taq RNA polymerase-rifampicin complex | x-ray diffraction | A, B | — | 5 (best 0.86) |
| 2GHO | Recombinant Thermus aquaticus RNA polymerase for Structural Studies | x-ray diffraction | A, B | — | 5 (best 0.70) |
| 2GHO | Recombinant thermus aquaticus RNA polymerase for structural studies | x-ray diffraction | A, B | — | 5 (best 0.70) |
| 4XLN | Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and… | x-ray diffraction | A, B, G, H | — | 4 (best 0.87) |
| 4XLN | Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and… | x-ray diffraction | A, B, G, H | — | 4 (best 0.87) |
| 4XLP | Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter | x-ray diffraction | A, B, G, H | — | 6 (best 0.86) |
| 4XLP | Crystal structure of T.AQUATICUS transcription initiation complex containing upstream fork promoter | x-ray diffraction | A, B, G, H | — | 6 (best 0.86) |
| 4XLQ | Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11… | x-ray diffraction | A, B, G, H | — | 7 (best 0.87) |
| 4XLQ | Crystal structure of T.AQUATICUS transcription initiation complex containing upstream fork (-11… | x-ray diffraction | A, B, G, H | — | 7 (best 0.87) |
| 4XLR | Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble… | x-ray diffraction | A, B, G, H | — | 4 (best 0.88) |
| 4XLR | Crystal structure of T.AQUATICUS transcription initiation complex with card containing bubble… | x-ray diffraction | A, B, G, H | — | 4 (best 0.88) |
| 4XLS | Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream… | x-ray diffraction | A, B, G, H | — | 5 (best 0.86) |
| 4XLS | Crystal structure of T. aquaticus transcription initiation complex with card containing upstream… | x-ray diffraction | A, B, G, H | — | 5 (best 0.86) |
| 5TJG | Thermus aquaticus delta1.1-sigmaA holoenzyme/downstream-fork promoter complex with an open clamp | x-ray diffraction | A, B | — | 6 (best 0.86) |
| 5TJG | Thermus aquaticus DELTA1.1-sigmaa HOLOENZYME/DOWNSTREAM-fork promoter complex with an open clamp | x-ray diffraction | A, B | — | 6 (best 0.86) |
| Q9KWU8 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q9KWU8) | predicted | A | — | 3 (best 0.43) |
Experiment against prediction
- 5TJG chain A against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.29 Å
- 5TJG chain A against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.29 Å
- 4XLP chain A against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.32 Å
- 4XLP chain A against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.32 Å
- 4XLP chain G against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.33 Å
- 1YNJ chain B against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.54 Å
- 1YNJ chain B against the predicted model Q9KWU8: TM-score 0.94, RMSD 1.54 Å
- 4XLS chain A against the predicted model Q9KWU8: TM-score 0.93, RMSD 1.39 Å
- 4XLS chain A against the predicted model Q9KWU8: TM-score 0.93, RMSD 1.39 Å
- 1I6V chain A against the predicted model Q9KWU8: TM-score 0.93, RMSD 1.59 Å
Elsewhere
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